BRD-K19220233_JNK-9L_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-K19220233_JNK-9L_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL1 adhesion G protein-coupled receptor L1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALB albumin
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
ASS1 argininosuccinate synthase 1
AVL9 AVL9 homolog (S. cerevisiase)
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
BID BH3 interacting domain death agonist
C10ORF2 chromosome 10 open reading frame 2
C2CD2L C2CD2-like
C3 complement component 3
CA11 carbonic anhydrase XI
CALML4 calmodulin-like 4
CAMP cathelicidin antimicrobial peptide
CARKD carbohydrate kinase domain containing
CCL13 chemokine (C-C motif) ligand 13
CCND1 cyclin D1
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CLCA4 chloride channel accessory 4
CLDN1 claudin 1
CLDN7 claudin 7
COASY CoA synthase
CRABP1 cellular retinoic acid binding protein 1
CTSG cathepsin G
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEFA4 defensin, alpha 4, corticostatin
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPT dermatopontin
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FGFR2 fibroblast growth factor receptor 2
FKBP1A FK506 binding protein 1A, 12kDa
FOLR1 folate receptor 1 (adult)
GAGE3 G antigen 3
GCA grancalcin, EF-hand calcium binding protein
GDF15 growth differentiation factor 15
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GTF2B general transcription factor IIB
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDAC9 histone deacetylase 9
HIST1H2BK histone cluster 1, H2bk
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOMER1 homer scaffolding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R2 interleukin 1 receptor, type II
IRF6 interferon regulatory factor 6
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
KRT23 keratin 23, type I
MAPT microtubule-associated protein tau
MICB MHC class I polypeptide-related sequence B
MMP3 matrix metallopeptidase 3
MOXD1 monooxygenase, DBH-like 1
NOP16 NOP16 nucleolar protein
ORM1 orosomucoid 1
PCP4 Purkinje cell protein 4
PDE2A phosphodiesterase 2A, cGMP-stimulated
PHKB phosphorylase kinase, beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPIF peptidylprolyl isomerase F
PRKCQ protein kinase C, theta
PRSS8 protease, serine, 8
RAB25 RAB25, member RAS oncogene family
RASA4 RAS p21 protein activator 4
RELN reelin
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPINT1 serine peptidase inhibitor, Kunitz type 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP2 syntaxin binding protein 2
SYNGR2 synaptogyrin 2
TBP TATA box binding protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF3 trefoil factor 3 (intestinal)
TMEM5 transmembrane protein 5
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TWIST1 twist family bHLH transcription factor 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WDR3 WD repeat domain 3
XIST X inactive specific transcript (non-protein coding)
ZNF12 zinc finger protein 12
ZNF263 zinc finger protein 263

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
AEBP1 AE binding protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
AUTS2 autism susceptibility candidate 2
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
CADM1 cell adhesion molecule 1
CASD1 CAS1 domain containing 1
CAST calpastatin
CAV2 caveolin 2
CCNB2 cyclin B2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHMP4A charged multivesicular body protein 4A
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
DAPK1 death-associated protein kinase 1
DCPS decapping enzyme, scavenger
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
DPYSL2 dihydropyrimidinase-like 2
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
ENG endoglin
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GLRX glutaredoxin (thioltransferase)
GSTA4 glutathione S-transferase alpha 4
GSTP1 glutathione S-transferase pi 1
GTPBP8 GTP-binding protein 8 (putative)
H1F0 H1 histone family, member 0
HIST1H4C histone cluster 1, H4c
HMGN3 high mobility group nucleosomal binding domain 3
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICAM2 intercellular adhesion molecule 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INA internexin neuronal intermediate filament protein, alpha
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KIAA1033 KIAA1033
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
LGALS3 lectin, galactoside-binding, soluble, 3
LXN latexin
LYPLA1 lysophospholipase I
MCM5 minichromosome maintenance complex component 5
MEIS2 Meis homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NRIP3 nuclear receptor interacting protein 3
PARP2 poly (ADP-ribose) polymerase 2
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSIP1 PC4 and SFRS1 interacting protein 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RBM34 RNA binding motif protein 34
RECQL RecQ helicase-like
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RIN2 Ras and Rab interactor 2
RNF167 ring finger protein 167
RPL37A ribosomal protein L37a
RPL39L ribosomal protein L39-like
SDPR serum deprivation response
SERINC3 serine incorporator 3
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBL1X transducin (beta)-like 1X-linked
TCEA1 transcription elongation factor A (SII), 1
TMEM50A transmembrane protein 50A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TOP2B topoisomerase (DNA) II beta 180kDa
VWF von Willebrand factor
WWTR1 WW domain containing transcription regulator 1
ZBTB38 zinc finger and BTB domain containing 38