BRD-K19220233_JNK-9L_BT20_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

278 genes differentially expressed following the BRD-K19220233_JNK-9L_BT20_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ACAA1 acetyl-CoA acyltransferase 1
ACTN1 actinin, alpha 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
AK4 adenylate kinase 4
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANKRD10 ankyrin repeat domain 10
APOE apolipoprotein E
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMCX2 armadillo repeat containing, X-linked 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AZIN1 antizyme inhibitor 1
BAG5 BCL2-associated athanogene 5
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BTG3 BTG family, member 3
C1ORF54 chromosome 1 open reading frame 54
C5AR1 complement component 5a receptor 1
CALB1 calbindin 1, 28kDa
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CLDN10 claudin 10
CLU clusterin
COPA coatomer protein complex, subunit alpha
CPE carboxypeptidase E
CTSB cathepsin B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP7 fatty acid binding protein 7, brain
FASTKD5 FAST kinase domains 5
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GCA grancalcin, EF-hand calcium binding protein
GCLC glutamate-cysteine ligase, catalytic subunit
GLS glutaminase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GSPT2 G1 to S phase transition 2
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JAM2 junctional adhesion molecule 2
KLHL21 kelch-like family member 21
KLK11 kallikrein-related peptidase 11
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMO4 LIM domain only 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP2 microtubule-associated protein 2
MCTP1 multiple C2 domains, transmembrane 1
MERTK MER proto-oncogene, tyrosine kinase
MICB MHC class I polypeptide-related sequence B
MOXD1 monooxygenase, DBH-like 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAMPT nicotinamide phosphoribosyltransferase
NGDN neuroguidin, EIF4E binding protein
NUPL1 nucleoporin like 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCP4 Purkinje cell protein 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG3 paternally expressed 3
PELO pelota homolog (Drosophila)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPRO protein tyrosine phosphatase, receptor type, O
RAE1 ribonucleic acid export 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASA4 RAS p21 protein activator 4
RBM15 RNA binding motif protein 15
RIOK3 RIO kinase 3
RNF144A ring finger protein 144A
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMG8 SMG8 nonsense mediated mRNA decay factor
SNN stannin
SPARCL1 SPARC-like 1 (hevin)
SPEN spen family transcriptional repressor
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STK17B serine/threonine kinase 17b
STK38L serine/threonine kinase 38 like
TFB2M transcription factor B2, mitochondrial
TFF3 trefoil factor 3 (intestinal)
TM7SF2 transmembrane 7 superfamily member 2
TNF tumor necrosis factor
TPP1 tripeptidyl peptidase I
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRH ubiquinol-cytochrome c reductase hinge protein
WT1 Wilms tumor 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB18 zinc finger and BTB domain containing 18
ZC3H11A zinc finger CCCH-type containing 11A
ZNF263 zinc finger protein 263

decreased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRG6 adhesion G protein-coupled receptor G6
AEBP1 AE binding protein 1
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
AK1 adenylate kinase 1
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP9A ATPase, class II, type 9A
AXL AXL receptor tyrosine kinase
BMI1 BMI1 proto-oncogene, polycomb ring finger
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW2 basic leucine zipper and W2 domains 2
CARD10 caspase recruitment domain family, member 10
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNB2 cyclin B2
CCND1 cyclin D1
CD200 CD200 molecule
CD24 CD24 molecule
CD58 CD58 molecule
CDC20 cell division cycle 20
COMMD3 COMM domain containing 3
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DCAF6 DDB1 and CUL4 associated factor 6
DCN decorin
DCPS decapping enzyme, scavenger
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ERBB2 erb-b2 receptor tyrosine kinase 2
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD2 FXYD domain containing ion transport regulator 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GAL galanin/GMAP prepropeptide
GALE UDP-galactose-4-epimerase
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTPBP8 GTP-binding protein 8 (putative)
GYG1 glycogenin 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HN1 hematological and neurological expressed 1
HOXB7 homeobox B7
HOXC10 homeobox C10
HOXC6 homeobox C6
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPB1 heat shock 27kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGSF3 immunoglobulin superfamily, member 3
IL7R interleukin 7 receptor
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT5 keratin 5, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LXN latexin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MYO1B myosin IB
MYO6 myosin VI
MYOF myoferlin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NRP1 neuropilin 1
NUP88 nucleoporin 88kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSBPL8 oxysterol binding protein-like 8
PCM1 pericentriolar material 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDS5A PDS5 cohesin associated factor A
PHACTR2 phosphatase and actin regulator 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PPAP2C phosphatidic acid phosphatase type 2C
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCD protein kinase C, delta
RAB31 RAB31, member RAS oncogene family
RALB v-ral simian leukemia viral oncogene homolog B
RHOBTB3 Rho-related BTB domain containing 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLPI secretory leukocyte peptidase inhibitor
STMN1 stathmin 1
STOM stomatin
SVIL supervillin
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TMEM2 transmembrane protein 2
TMEM50A transmembrane protein 50A
TNNC1 troponin C type 1 (slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TUBA1A tubulin, alpha 1a
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
WNT5A wingless-type MMTV integration site family, member 5A