BRD-K19220233_-666_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

318 genes differentially expressed following the BRD-K19220233_-666_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ANXA4 annexin A4
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AREG amphiregulin
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CD52 CD52 molecule
CD9 CD9 molecule
CDH13 cadherin 13
CECR1 cat eye syndrome chromosome region, candidate 1
CERS6 ceramide synthase 6
CETN2 centrin, EF-hand protein, 2
CLGN calmegin
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL4A6 collagen, type IV, alpha 6
COMMD8 COMM domain containing 8
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EREG epiregulin
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FZD6 frizzled class receptor 6
GAS6 growth arrest-specific 6
GLG1 golgi glycoprotein 1
GPX3 glutathione peroxidase 3
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HRSP12 heat-responsive protein 12
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
INA internexin neuronal intermediate filament protein, alpha
ISYNA1 inositol-3-phosphate synthase 1
ITM2C integral membrane protein 2C
KRT19 keratin 19, type I
KRT8 keratin 8, type II
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MLF1 myeloid leukemia factor 1
MN1 meningioma (disrupted in balanced translocation) 1
MUC16 mucin 16, cell surface associated
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLAT plasminogen activator, tissue
PON3 paraoxonase 3
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRAME preferentially expressed antigen in melanoma
PSPH phosphoserine phosphatase
RAG1 recombination activating gene 1
RGCC regulator of cell cycle
RTN1 reticulon 1
SCG2 secretogranin II
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TP53I3 tumor protein p53 inducible protein 3
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3
UGP2 UDP-glucose pyrophosphorylase 2
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZDHHC13 zinc finger, DHHC-type containing 13

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AKAP8 A kinase (PRKA) anchor protein 8
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AMACR alpha-methylacyl-CoA racemase
AMD1 adenosylmethionine decarboxylase 1
APOL2 apolipoprotein L, 2
AQP3 aquaporin 3 (Gill blood group)
ARL4A ADP-ribosylation factor-like 4A
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BRPF1 bromodomain and PHD finger containing, 1
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEP76 centrosomal protein 76kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CREBBP CREB binding protein
CST1 cystatin SN
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADD Fas (TNFRSF6)-associated via death domain
FAM46A family with sequence similarity 46, member A
FAM98A family with sequence similarity 98, member A
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FKBP11 FK506 binding protein 11, 19 kDa
FOXC1 forkhead box C1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD7 frizzled class receptor 7
GATA2 GATA binding protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GNAS GNAS complex locus
GOSR1 golgi SNAP receptor complex member 1
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
HES1 hes family bHLH transcription factor 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
IER2 immediate early response 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MEPCE methylphosphate capping enzyme
MRFAP1L1 Morf4 family associated protein 1-like 1
MSH6 mutS homolog 6
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
NET1 neuroepithelial cell transforming 1
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PI3 peptidase inhibitor 3, skin-derived
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTRH2 peptidyl-tRNA hydrolase 2
PWP1 PWP1 homolog (S. cerevisiae)
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM12 RNA binding motif protein 12
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF111 ring finger protein 111
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
S100A7 S100 calcium binding protein A7
SACS sacsin molecular chaperone
SAR1A secretion associated, Ras related GTPase 1A
SCAF8 SR-related CTD-associated factor 8
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC25A44 solute carrier family 25, member 44
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRK SNF related kinase
SNRPE small nuclear ribonucleoprotein polypeptide E
SNX11 sorting nexin 11
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SPATA5L1 spermatogenesis associated 5-like 1
SRPRB signal recognition particle receptor, B subunit
SRSF2 serine/arginine-rich splicing factor 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TGFBR3 transforming growth factor, beta receptor III
TICAM1 toll-like receptor adaptor molecule 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMPO thymopoietin
TNPO1 transportin 1
TRIM27 tripartite motif containing 27
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TXLNA taxilin alpha
UBAP2L ubiquitin associated protein 2-like
UBE2S ubiquitin-conjugating enzyme E2S
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZBTB24 zinc finger and BTB domain containing 24
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF146 zinc finger protein 146
ZNF263 zinc finger protein 263
ZNF330 zinc finger protein 330
ZNF574 zinc finger protein 574