BRD-K19220233_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K19220233_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADAMTSL3 ADAMTS-like 3
AHNAK2 AHNAK nucleoprotein 2
ASPN asporin
BAX BCL2-associated X protein
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD69 CD69 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL18A1 collagen, type XVIII, alpha 1
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GRB14 growth factor receptor-bound protein 14
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPG2 heparan sulfate proteoglycan 2
ICAM3 intercellular adhesion molecule 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2A integral membrane protein 2A
KDR kinase insert domain receptor
L1CAM L1 cell adhesion molecule
LAMP2 lysosomal-associated membrane protein 2
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
NEBL nebulette
NRP1 neuropilin 1
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG3 paternally expressed 3
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPL periplakin
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
TDO2 tryptophan 2,3-dioxygenase
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BLCAP bladder cancer associated protein
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHERP calcium homeostasis endoplasmic reticulum protein
CNOT4 CCR4-NOT transcription complex, subunit 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP7 dual specificity phosphatase 7
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FBXO21 F-box protein 21
FEN1 flap structure-specific endonuclease 1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD7 frizzled class receptor 7
GCLM glutamate-cysteine ligase, modifier subunit
GLIPR1 GLI pathogenesis-related 1
GOLPH3L golgi phosphoprotein 3-like
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
HOXA5 homeobox A5
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
MBNL2 muscleblind-like splicing regulator 2
MEPCE methylphosphate capping enzyme
MRFAP1L1 Morf4 family associated protein 1-like 1
MTF2 metal response element binding transcription factor 2
NOP16 NOP16 nucleolar protein
NUP62 nucleoporin 62kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PHF20 PHD finger protein 20
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLK2 polo-like kinase 2
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PRUNE prune exopolyphosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RIN2 Ras and Rab interactor 2
RNMT RNA (guanine-7-) methyltransferase
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TEX10 testis expressed 10
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOB2 transducer of ERBB2, 2
TRAPPC3 trafficking protein particle complex 3
TRIB3 tribbles pseudokinase 3
TSKU tsukushi, small leucine rich proteoglycan
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
VCAN versican