BRD-K19181733_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

52 genes differentially expressed following the BRD-K19181733_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ADGRF5 adhesion G protein-coupled receptor F5
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
CCL20 chemokine (C-C motif) ligand 20
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FAM65B family with sequence similarity 65, member B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
OLFM1 olfactomedin 1
OSBPL10 oxysterol binding protein-like 10
PLAGL1 pleiomorphic adenoma gene-like 1
PSAT1 phosphoserine aminotransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SST somatostatin
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
CA2 carbonic anhydrase II
CD9 CD9 molecule
FOXG1 forkhead box G1
FPGS folylpolyglutamate synthase
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
ZSCAN18 zinc finger and SCAN domain containing 18