BRD-K19181733_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K19181733_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CD163 CD163 molecule
CD24 CD24 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CERS6 ceramide synthase 6
CPA3 carboxypeptidase A3 (mast cell)
CST1 cystatin SN
CTSK cathepsin K
CUTA cutA divalent cation tolerance homolog (E. coli)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR7 7-dehydrocholesterol reductase
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
ECM1 extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
F11R F11 receptor
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FN1 fibronectin 1
FOXO3 forkhead box O3
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
MXI1 MAX interactor 1, dimerization protein
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPIPB3 nuclear pore complex interacting protein family, member B3
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PHGDH phosphoglycerate dehydrogenase
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERINC5 serine incorporator 5
SFRP4 secreted frizzled-related protein 4
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SOX9 SRY (sex determining region Y)-box 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUBB2B tubulin, beta 2B class IIb
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASF1B anti-silencing function 1B histone chaperone
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CENPN centromere protein N
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CLU clusterin
CMC2 C-x(9)-C motif containing 2
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EED embryonic ectoderm development
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAGE3 L antigen family, member 3
LIG1 ligase I, DNA, ATP-dependent
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MYCBP MYC binding protein
NCAPG2 non-SMC condensin II complex, subunit G2
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
SMC2 structural maintenance of chromosomes 2
SNRPG small nuclear ribonucleoprotein polypeptide G
SPDL1 spindle apparatus coiled-coil protein 1
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TFAM transcription factor A, mitochondrial
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
ZNF185 zinc finger protein 185 (LIM domain)
ZWINT ZW10 interacting kinetochore protein