BRD-K18909381_CGS 12066B_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K18909381_CGS 12066B_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACOT7 acyl-CoA thioesterase 7
AHNAK2 AHNAK nucleoprotein 2
ARG1 arginase 1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C14ORF132 chromosome 14 open reading frame 132
C7 complement component 7
CCND2 cyclin D2
CD52 CD52 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
CLGN calmegin
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
DEFA4 defensin, alpha 4, corticostatin
DES desmin
DHCR7 7-dehydrocholesterol reductase
DTX4 deltex 4, E3 ubiquitin ligase
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FTH1 ferritin, heavy polypeptide 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NTS neurotensin
PEG3 paternally expressed 3
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SOX2 SRY (sex determining region Y)-box 2
SPRR3 small proline-rich protein 3
SQLE squalene epoxidase
STOM stomatin
TM7SF2 transmembrane 7 superfamily member 2

decreased expression

Symbol Name
AK2 adenylate kinase 2
ANXA2 annexin A2
CCL2 chemokine (C-C motif) ligand 2
CD99 CD99 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
COL11A1 collagen, type XI, alpha 1
EFNB2 ephrin-B2
ENO1 enolase 1, (alpha)
ESR1 estrogen receptor 1
FAM60A family with sequence similarity 60, member A
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
LOX lysyl oxidase
LY75 lymphocyte antigen 75
MINA MYC induced nuclear antigen
MOK MOK protein kinase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDLIM5 PDZ and LIM domain 5
PLAU plasminogen activator, urokinase
POSTN periostin, osteoblast specific factor
REEP5 receptor accessory protein 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SMYD2 SET and MYND domain containing 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM4 tropomyosin 4