BRD-K18861610_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K18861610_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCHE butyrylcholinesterase
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
COL4A2 collagen, type IV, alpha 2
GATA3 GATA binding protein 3
GRN granulin
GSTT1 glutathione S-transferase theta 1
IDO1 indoleamine 2,3-dioxygenase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LOX lysyl oxidase
MCL1 myeloid cell leukemia 1
NES nestin
NR1H2 nuclear receptor subfamily 1, group H, member 2
OSBPL10 oxysterol binding protein-like 10
POSTN periostin, osteoblast specific factor
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RGCC regulator of cell cycle
RTN1 reticulon 1
SCN3A sodium channel, voltage gated, type III alpha subunit
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRDV3 T cell receptor delta variable 3
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AHCY adenosylhomocysteinase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANXA1 annexin A1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BEX1 brain expressed, X-linked 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CLU clusterin
COL21A1 collagen, type XXI, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CXCL5 chemokine (C-X-C motif) ligand 5
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
EBP emopamil binding protein (sterol isomerase)
ELF1 E74-like factor 1 (ets domain transcription factor)
ERBB2 erb-b2 receptor tyrosine kinase 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FYN FYN proto-oncogene, Src family tyrosine kinase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
IRS2 insulin receptor substrate 2
LAMP5 lysosomal-associated membrane protein family, member 5
LEPR leptin receptor
MET MET proto-oncogene, receptor tyrosine kinase
MPO myeloperoxidase
PDGFC platelet derived growth factor C
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100P S100 calcium binding protein P
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS4 thrombospondin 4
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5