BRD-K18787491_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

255 genes differentially expressed following the BRD-K18787491_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACAA1 acetyl-CoA acyltransferase 1
ACACB acetyl-CoA carboxylase beta
ACSF2 acyl-CoA synthetase family member 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANKMY2 ankyrin repeat and MYND domain containing 2
APLP2 amyloid beta (A4) precursor-like protein 2
ARMT1 acidic residue methyltransferase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BRD8 bromodomain containing 8
CCNG2 cyclin G2
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPE centromere protein E, 312kDa
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CLU clusterin
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSA cathepsin A
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPB1 heat shock 27kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIR pirin (iron-binding nuclear protein)
POR P450 (cytochrome) oxidoreductase
PRKCD protein kinase C, delta
PRR15L proline rich 15-like
PSCA prostate stem cell antigen
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
RXRA retinoid X receptor, alpha
SELENBP1 selenium binding protein 1
SESN1 sestrin 1
SIDT2 SID1 transmembrane family, member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SUOX sulfite oxidase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
UBE2A ubiquitin-conjugating enzyme E2A
VWA5A von Willebrand factor A domain containing 5A
WBP1L WW domain binding protein 1-like
WFDC2 WAP four-disulfide core domain 2
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIM2 absent in melanoma 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
AXIN1 axin 1
BCL2A1 BCL2-related protein A1
BOP1 block of proliferation 1
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
CCDC85B coiled-coil domain containing 85B
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD3EAP CD3e molecule, epsilon associated protein
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKAP4 cytoskeleton-associated protein 4
CTPS1 CTP synthase 1
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
E2F5 E2F transcription factor 5, p130-binding
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
EREG epiregulin
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FERMT1 fermitin family member 1
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GLS glutaminase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
IER2 immediate early response 2
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KIAA0020 KIAA0020
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LOXL1 lysyl oxidase-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP1B microtubule-associated protein 1B
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MINA MYC induced nuclear antigen
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NELL2 NEL-like 2 (chicken)
NFE2L3 nuclear factor, erythroid 2-like 3
NIP7 NIP7, nucleolar pre-rRNA processing protein
NLE1 notchless homolog 1 (Drosophila)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAEP progestagen-associated endometrial protein
PAK1IP1 PAK1 interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLK2 polo-like kinase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRNP prion protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTRH2 peptidyl-tRNA hydrolase 2
PUS7 pseudouridylate synthase 7 (putative)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS2 regulator of G-protein signaling 2
RIPK2 receptor-interacting serine-threonine kinase 2
RPP40 ribonuclease P/MRP 40kDa subunit
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SDCCAG3 serologically defined colon cancer antigen 3
SEH1L SEH1-like (S. cerevisiae)
SEPT10 septin 10
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC35F2 solute carrier family 35, member F2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRM spermidine synthase
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPD52 tumor protein D52
TPM4 tropomyosin 4
TRIB1 tribbles pseudokinase 1
TRIB2 tribbles pseudokinase 2
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
UCK2 uridine-cytidine kinase 2
UPP1 uridine phosphorylase 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
WDR74 WD repeat domain 74
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing