BRD-K18787491_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K18787491_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ASS1 argininosuccinate synthase 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BEX4 brain expressed, X-linked 4
BLVRB biliverdin reductase B
CLCA2 chloride channel accessory 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FDXR ferredoxin reductase
HOXC6 homeobox C6
MAP7 microtubule-associated protein 7
NEFH neurofilament, heavy polypeptide
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
RTN2 reticulon 2
TDO2 tryptophan 2,3-dioxygenase
TPD52L1 tumor protein D52-like 1
VCAM1 vascular cell adhesion molecule 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
BCAR3 breast cancer anti-estrogen resistance 3
BMP2 bone morphogenetic protein 2
CBFB core-binding factor, beta subunit
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CTGF connective tissue growth factor
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV1 ets variant 1
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSAP gamma-secretase activating protein
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
ITGA6 integrin, alpha 6
JAG1 jagged 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MOK MOK protein kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
PGC progastricsin (pepsinogen C)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPARG peroxisome proliferator-activated receptor gamma
PPAT phosphoribosyl pyrophosphate amidotransferase
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RGS4 regulator of G-protein signaling 4
SLC35F2 solute carrier family 35, member F2
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB2 tribbles pseudokinase 2