BRD-K18749194_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K18749194_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
CADM1 cell adhesion molecule 1
CELF2 CUGBP, Elav-like family member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CXCL12 chemokine (C-X-C motif) ligand 12
DACT1 dishevelled-binding antagonist of beta-catenin 1
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FST follistatin
GPX3 glutathione peroxidase 3
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
JAM2 junctional adhesion molecule 2
L1CAM L1 cell adhesion molecule
LRRC15 leucine rich repeat containing 15
MGLL monoglyceride lipase
MUC2 mucin 2, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
PHGDH phosphoglycerate dehydrogenase
QKI QKI, KH domain containing, RNA binding
RABGGTB Rab geranylgeranyltransferase, beta subunit
RPL38 ribosomal protein L38
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35G2 solute carrier family 35, member G2
SOX9 SRY (sex determining region Y)-box 9
STC2 stanniocalcin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB2B tubulin, beta 2B class IIb
VCAM1 vascular cell adhesion molecule 1
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ARID4B AT rich interactive domain 4B (RBP1-like)
BANK1 B-cell scaffold protein with ankyrin repeats 1
C3 complement component 3
CAV2 caveolin 2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLCA2 chloride channel accessory 2
CSTA cystatin A (stefin A)
CTSH cathepsin H
DPP4 dipeptidyl-peptidase 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FZD6 frizzled class receptor 6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IQGAP1 IQ motif containing GTPase activating protein 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6A keratin 6A, type II
LAMP3 lysosomal-associated membrane protein 3
LGALS2 lectin, galactoside-binding, soluble, 2
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MECOM MDS1 and EVI1 complex locus
MELK maternal embryonic leucine zipper kinase
MSMB microseminoprotein, beta-
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEK2 NIMA-related kinase 2
PBK PDZ binding kinase
PERP PERP, TP53 apoptosis effector
PRAME preferentially expressed antigen in melanoma
REEP1 receptor accessory protein 1
RRM2 ribonucleotide reductase M2
SCN3A sodium channel, voltage gated, type III alpha subunit
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMEM14A transmembrane protein 14A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52 tumor protein D52
TXNIP thioredoxin interacting protein
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VAMP8 vesicle-associated membrane protein 8
WEE1 WEE1 G2 checkpoint kinase
ZDHHC11 zinc finger, DHHC-type containing 11
ZWINT ZW10 interacting kinetochore protein