BRD-K18726304_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K18726304_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTB actin, beta
ACTN1 actinin, alpha 1
ADORA2B adenosine A2b receptor
AGR2 anterior gradient 2
AKAP8L A kinase (PRKA) anchor protein 8-like
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BASP1 brain abundant, membrane attached signal protein 1
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CDK19 cyclin-dependent kinase 19
CKB creatine kinase, brain
CLIC5 chloride intracellular channel 5
COCH cochlin
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CSNK2A2 casein kinase 2, alpha prime polypeptide
CST1 cystatin SN
CTSV cathepsin V
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DST dystonin
DUSP10 dual specificity phosphatase 10
EGR2 early growth response 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM171A1 family with sequence similarity 171, member A1
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
FNBP1 formin binding protein 1
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GPR183 G protein-coupled receptor 183
GRN granulin
H3F3B H3 histone, family 3B (H3.3B)
HECA headcase homolog (Drosophila)
IGLJ3 immunoglobulin lambda joining 3
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
LAMP3 lysosomal-associated membrane protein 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNA lamin A/C
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MICALL1 MICAL-like 1
MYO6 myosin VI
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NID1 nidogen 1
NT5E 5'-nucleotidase, ecto (CD73)
PBX3 pre-B-cell leukemia homeobox 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PEG10 paternally expressed 10
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCA protein kinase C, alpha
PRKCH protein kinase C, eta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RHOBTB3 Rho-related BTB domain containing 3
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
SENP6 SUMO1/sentrin specific peptidase 6
SFRP1 secreted frizzled-related protein 1
SORBS1 sorbin and SH3 domain containing 1
SOSTDC1 sclerostin domain containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STON1 stonin 1
SYNM synemin, intermediate filament protein
TBX2 T-box 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM255A transmembrane protein 255A
TOX3 TOX high mobility group box family member 3
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
UBE3B ubiquitin protein ligase E3B

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CCNA2 cyclin A2
CCNF cyclin F
CDCA4 cell division cycle associated 4
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN7 claudin 7
CXCL14 chemokine (C-X-C motif) ligand 14
DENND2D DENN/MADD domain containing 2D
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUOX2 dual oxidase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4A1 eukaryotic translation initiation factor 4A1
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H4J histone cluster 1, H4j
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KIF14 kinesin family member 14
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
METTL7A methyltransferase like 7A
MTERF3 mitochondrial transcription termination factor 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NARFL nuclear prelamin A recognition factor-like
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PDGFRL platelet-derived growth factor receptor-like
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PROM1 prominin 1
PRR15L proline rich 15-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RND3 Rho family GTPase 3
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
SMIM7 small integral membrane protein 7
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TMEM97 transmembrane protein 97
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
UGCG UDP-glucose ceramide glucosyltransferase
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)