BRD-K18726304_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K18726304_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ASPN asporin
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BAMBI BMP and activin membrane-bound inhibitor
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCND2 cyclin D2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CSNK2A2 casein kinase 2, alpha prime polypeptide
CXCL10 chemokine (C-X-C motif) ligand 10
DCN decorin
DUSP6 dual specificity phosphatase 6
EMX2 empty spiracles homeobox 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM134B family with sequence similarity 134, member B
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GALC galactosylceramidase
GATA2 GATA binding protein 2
GLUL glutamate-ammonia ligase
GRB10 growth factor receptor-bound protein 10
GSTZ1 glutathione S-transferase zeta 1
HSPA1A heat shock 70kDa protein 1A
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
KIAA0930 KIAA0930
KLF11 Kruppel-like factor 11
KRT5 keratin 5, type II
LPAR2 lysophosphatidic acid receptor 2
MAOB monoamine oxidase B
MMP12 matrix metallopeptidase 12
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO6 myosin VI
NCF2 neutrophil cytosolic factor 2
NID1 nidogen 1
NXN nucleoredoxin
OSR2 odd-skipped related transciption factor 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
RAB25 RAB25, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RBM8A RNA binding motif protein 8A
RGS16 regulator of G-protein signaling 16
RNF19B ring finger protein 19B
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STX3 syntaxin 3
TCF4 transcription factor 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOB aldolase B, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
ANPEP alanyl (membrane) aminopeptidase
BIN1 bridging integrator 1
C7 complement component 7
CALB1 calbindin 1, 28kDa
CAST calpastatin
CCNA2 cyclin A2
CCND1 cyclin D1
CD24 CD24 molecule
CHMP6 charged multivesicular body protein 6
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
EGFR epidermal growth factor receptor
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
FPGS folylpolyglutamate synthase
FUS FUS RNA binding protein
GABPB1 GA binding protein transcription factor, beta subunit 1
GLIPR1 GLI pathogenesis-related 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MATN2 matrilin 2
MME membrane metallo-endopeptidase
MRPL15 mitochondrial ribosomal protein L15
MRPS16 mitochondrial ribosomal protein S16
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRSS2 protease, serine, 2 (trypsin 2)
PTX3 pentraxin 3, long
PWP1 PWP1 homolog (S. cerevisiae)
RPL22 ribosomal protein L22
SKAP2 src kinase associated phosphoprotein 2
SPINK1 serine peptidase inhibitor, Kazal type 1
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TXNDC9 thioredoxin domain containing 9
TYRP1 tyrosinase-related protein 1
U2AF1 U2 small nuclear RNA auxiliary factor 1
VCAM1 vascular cell adhesion molecule 1
ZMIZ1 zinc finger, MIZ-type containing 1