BRD-K18726304_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K18726304_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ARID4B AT rich interactive domain 4B (RBP1-like)
ASS1 argininosuccinate synthase 1
ATF5 activating transcription factor 5
BTG2 BTG family, member 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
CLU clusterin
COL5A1 collagen, type V, alpha 1
CTSZ cathepsin Z
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DSE dermatan sulfate epimerase
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
KCTD12 potassium channel tetramerization domain containing 12
KDM5A lysine (K)-specific demethylase 5A
LCN2 lipocalin 2
MAOB monoamine oxidase B
MAPT microtubule-associated protein tau
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCF2 neutrophil cytosolic factor 2
NFIB nuclear factor I/B
PDGFA platelet-derived growth factor alpha polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRE protein tyrosine phosphatase, receptor type, E
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SESN1 sestrin 1
SLC46A3 solute carrier family 46, member 3
SULF1 sulfatase 1
TKTL1 transketolase-like 1
TNS1 tensin 1
TP53 tumor protein p53
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BEX1 brain expressed, X-linked 1
CCND1 cyclin D1
CCNF cyclin F
CDCA4 cell division cycle associated 4
CPB1 carboxypeptidase B1 (tissue)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FXYD3 FXYD domain containing ion transport regulator 3
GPNMB glycoprotein (transmembrane) nmb
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
ITGA6 integrin, alpha 6
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LOC100505650 uncharacterized LOC100505650
MAP7 microtubule-associated protein 7
MOK MOK protein kinase
MRPL12 mitochondrial ribosomal protein L12
MUC7 mucin 7, secreted
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
PAM peptidylglycine alpha-amidating monooxygenase
PARP2 poly (ADP-ribose) polymerase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PIR pirin (iron-binding nuclear protein)
PTX3 pentraxin 3, long
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SRI sorcin
SYBU syntabulin (syntaxin-interacting)
TBX3 T-box 3
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS3 tensin 3