BRD-K18518344_Digitoxigenin_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K18518344_Digitoxigenin_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
AEBP1 AE binding protein 1
AKR1C2 aldo-keto reductase family 1, member C2
AREG amphiregulin
ARG2 arginase 2
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC5A C-type lectin domain family 5, member A
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
ENAH enabled homolog (Drosophila)
EZR ezrin
FAM60A family with sequence similarity 60, member A
FASN fatty acid synthase
FBLN1 fibulin 1
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
H1FX H1 histone family, member X
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-G major histocompatibility complex, class I, G
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL6 interleukin 6
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KLF6 Kruppel-like factor 6
LAMP3 lysosomal-associated membrane protein 3
LRRC15 leucine rich repeat containing 15
MALL mal, T-cell differentiation protein-like
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NXN nucleoredoxin
PAWR PRKC, apoptosis, WT1, regulator
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
STC1 stanniocalcin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AMZ2 archaelysin family metallopeptidase 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATMIN ATM interactor
C6ORF62 chromosome 6 open reading frame 62
C8ORF33 chromosome 8 open reading frame 33
CA2 carbonic anhydrase II
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CCND2 cyclin D2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CMC4 C-x(9)-C motif containing 4
CSK c-src tyrosine kinase
CX3CR1 chemokine (C-X3-C motif) receptor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF5 eukaryotic translation initiation factor 5
FAR2 fatty acyl CoA reductase 2
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
HSPA8 heat shock 70kDa protein 8
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
MAT2A methionine adenosyltransferase II, alpha
MOCS2 molybdenum cofactor synthesis 2
MRPL15 mitochondrial ribosomal protein L15
NREP neuronal regeneration related protein
PDGFA platelet-derived growth factor alpha polypeptide
PLAT plasminogen activator, tissue
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RRAGD Ras-related GTP binding D
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
THYN1 thymocyte nuclear protein 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMX4 thioredoxin-related transmembrane protein 4
TPBG trophoblast glycoprotein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAM1 vascular cell adhesion molecule 1
XBP1 X-box binding protein 1
ZNF32 zinc finger protein 32