BRD-K18163752_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K18163752_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BTG1 B-cell translocation gene 1, anti-proliferative
CD163 CD163 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RHOB ras homolog family member B
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TGFBI transforming growth factor, beta-induced, 68kDa
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
AIM1 absent in melanoma 1
ANKRD10 ankyrin repeat domain 10
ARHGAP29 Rho GTPase activating protein 29
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATF5 activating transcription factor 5
CANT1 calcium activated nucleotidase 1
CCNE2 cyclin E2
CD81 CD81 molecule
CD9 CD9 molecule
CDC25A cell division cycle 25A
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DEGS1 delta(4)-desaturase, sphingolipid 1
DUT deoxyuridine triphosphatase
EFNB2 ephrin-B2
F2R coagulation factor II (thrombin) receptor
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5B G protein-coupled receptor, class C, group 5, member B
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KIAA0101 KIAA0101
KRT14 keratin 14, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MREG melanoregulin
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUAK1 NUAK family, SNF1-like kinase, 1
OSBPL10 oxysterol binding protein-like 10
PCNA proliferating cell nuclear antigen
PLAT plasminogen activator, tissue
PLXNA1 plexin A1
PTN pleiotrophin
RBM3 RNA binding motif (RNP1, RRM) protein 3
RRM2 ribonucleotide reductase M2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SESN1 sestrin 1
SLBP stem-loop binding protein
SMS spermine synthase
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TYMS thymidylate synthetase
ZWINT ZW10 interacting kinetochore protein