BRD-K18163752_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

244 genes differentially expressed following the BRD-K18163752_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSL cathepsin L
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPRS glutamyl-prolyl-tRNA synthetase
FOLR1 folate receptor 1 (adult)
FOXD1 forkhead box D1
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IARS isoleucyl-tRNA synthetase
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOTCH1 notch 1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMOX spermine oxidase
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
SYNGR3 synaptogyrin 3
TBL2 transducin (beta)-like 2
TGFA transforming growth factor, alpha
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TTC17 tetratricopeptide repeat domain 17
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ADI1 acireductone dioxygenase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
B3GNT1
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DEK DEK proto-oncogene
DHFR dihydrofolate reductase
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYD dihydropyrimidine dehydrogenase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
ISOC1 isochorismatase domain containing 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MKI67 marker of proliferation Ki-67
MRPL16 mitochondrial ribosomal protein L16
MYBPC1 myosin binding protein C, slow type
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NELL2 NEL-like 2 (chicken)
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NT5DC2 5'-nucleotidase domain containing 2
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX3 peroxiredoxin 3
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD51C RAD51 paralog C
RAD54B RAD54 homolog B (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELN reelin
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A13 S100 calcium binding protein A13
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SRSF1 serine/arginine-rich splicing factor 1
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TK1 thymidine kinase 1, soluble
TMEM106C transmembrane protein 106C
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UNG uracil-DNA glycosylase
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
VDAC1 voltage-dependent anion channel 1
ZWINT ZW10 interacting kinetochore protein