BRD-K18059238_GAMMA-LINOLENIC ACID (18:3 n-6)_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-K18059238_GAMMA-LINOLENIC ACID (18:3 n-6)_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAT1 adenosine deaminase, tRNA-specific 1
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
ASPN asporin
BLNK B-cell linker
BMP4 bone morphogenetic protein 4
BTG2 BTG family, member 2
C1QB complement component 1, q subcomponent, B chain
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD24 CD24 molecule
CD86 CD86 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CECR1 cat eye syndrome chromosome region, candidate 1
CHGB chromogranin B
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNND1 catenin (cadherin-associated protein), delta 1
CTSH cathepsin H
CTSZ cathepsin Z
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
DENND1B DENN/MADD domain containing 1B
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPCAM epithelial cell adhesion molecule
ESRP1 epithelial splicing regulatory protein 1
EVI2A ecotropic viral integration site 2A
FAM69A family with sequence similarity 69, member A
FAP fibroblast activation protein, alpha
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGD6 FYVE, RhoGEF and PH domain containing 6
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GCLC glutamate-cysteine ligase, catalytic subunit
GPNMB glycoprotein (transmembrane) nmb
GSDMB gasdermin B
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
INHBB inhibin, beta B
IPO13 importin 13
IRF6 interferon regulatory factor 6
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0930 KIAA0930
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT18 keratin 18, type I
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
LYZ lysozyme
MAOA monoamine oxidase A
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MXRA5 matrix-remodelling associated 5
NCAPD2 non-SMC condensin I complex, subunit D2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEB nebulin
NELL2 NEL-like 2 (chicken)
NFE2L3 nuclear factor, erythroid 2-like 3
NIT1 nitrilase 1
NPTX2 neuronal pentraxin II
NTS neurotensin
NUAK1 NUAK family, SNF1-like kinase, 1
ORC1 origin recognition complex, subunit 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4A phosphodiesterase 4A, cAMP-specific
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLVAP plasmalemma vesicle associated protein
PRR15L proline rich 15-like
PTPRF protein tyrosine phosphatase, receptor type, F
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
S100A1 S100 calcium binding protein A1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNX13 sorting nexin 13
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TYROBP TYRO protein tyrosine kinase binding protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XCL1 chemokine (C motif) ligand 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
ANXA5 annexin A5
BST2 bone marrow stromal cell antigen 2
C6ORF48 chromosome 6 open reading frame 48
CANT1 calcium activated nucleotidase 1
CCNG1 cyclin G1
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHL1 cell adhesion molecule L1-like
CLINT1 clathrin interactor 1
COASY CoA synthase
CREB3L2 cAMP responsive element binding protein 3-like 2
CRNN cornulin
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEFB1 defensin, beta 1
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EPN2 epsin 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HOXC6 homeobox C6
IL6ST interleukin 6 signal transducer
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIAA0125 KIAA0125
KLF2 Kruppel-like factor 2
KRT10 keratin 10, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEPR leptin receptor
LPL lipoprotein lipase
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOTCH2 notch 2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
OXTR oxytocin receptor
PCM1 pericentriolar material 1
PCYOX1L prenylcysteine oxidase 1 like
PHB prohibitin
PI3 peptidase inhibitor 3, skin-derived
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLAC8 placenta-specific 8
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTGES prostaglandin E synthase
RBMS1 RNA binding motif, single stranded interacting protein 1
RPN2 ribophorin II
RPS26 ribosomal protein S26
SACS sacsin molecular chaperone
SEC24A SEC24 family member A
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SKP1 S-phase kinase-associated protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35B1 solute carrier family 35, member B1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TRAM1 translocation associated membrane protein 1
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
XBP1 X-box binding protein 1