BRD-K17953061_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

249 genes differentially expressed following the BRD-K17953061_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADGRL4 adhesion G protein-coupled receptor L4
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALDOB aldolase B, fructose-bisphosphate
ANXA1 annexin A1
ANXA4 annexin A4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND2 cyclin D2
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CFB complement factor B
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CTSK cathepsin K
CYBRD1 cytochrome b reductase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FSD1 fibronectin type III and SPRY domain containing 1
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
IDO1 indoleamine 2,3-dioxygenase 1
IL13RA1 interleukin 13 receptor, alpha 1
LAPTM4B lysosomal protein transmembrane 4 beta
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPK1 mitogen-activated protein kinase 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MYOF myoferlin
NMU neuromedin U
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PEG10 paternally expressed 10
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRAME preferentially expressed antigen in melanoma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB13 RAB13, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNAP29 synaptosomal-associated protein, 29kDa
SOCS2 suppressor of cytokine signaling 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCF4 transcription factor 4
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TPM2 tropomyosin 2 (beta)
UGP2 UDP-glucose pyrophosphorylase 2
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BRD2 bromodomain containing 2
BRPF1 bromodomain and PHD finger containing, 1
BST2 bone marrow stromal cell antigen 2
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CLU clusterin
COIL coilin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPF2 D4, zinc and double PHD fingers family 2
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
FA2H fatty acid 2-hydroxylase
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GNAS GNAS complex locus
GOSR1 golgi SNAP receptor complex member 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HEXIM1 hexamethylene bis-acetamide inducible 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD5 potassium channel tetramerization domain containing 5
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KIN Kin17 DNA and RNA binding protein
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KYNU kynureninase
LAT2 linker for activation of T cells family, member 2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY86 lymphocyte antigen 86
MAGEA1 melanoma antigen family A1
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MSL2 male-specific lethal 2 homolog (Drosophila)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL11 nucleolar protein 11
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
PER2 period circadian clock 2
PFKP phosphofructokinase, platelet
PLA2G15 phospholipase A2, group XV
PLAC8 placenta-specific 8
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PTGES prostaglandin E synthase
RABIF RAB interacting factor
RBM15 RNA binding motif protein 15
RLF rearranged L-myc fusion
RNH1 ribonuclease/angiogenin inhibitor 1
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RYBP RING1 and YY1 binding protein
SATB1 SATB homeobox 1
SCAF8 SR-related CTD-associated factor 8
SELL selectin L
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SETD5 SET domain containing 5
SFN stratifin
SIX1 SIX homeobox 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
STIL SCL/TAL1 interrupting locus
STK26 serine/threonine protein kinase 26
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TBX2 T-box 2
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TLE3 transducin-like enhancer of split 3
TLK2 tousled-like kinase 2
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP6NL USP6 N-terminal like
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB11 zinc finger and BTB domain containing 11
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF217 zinc finger protein 217
ZNF443 zinc finger protein 443