BRD-K17953061_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

308 genes differentially expressed following the BRD-K17953061_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD17A abhydrolase domain containing 17A
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ADM adrenomedullin
AIDA axin interactor, dorsalization associated
ALB albumin
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EDN1 endothelin 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM198B family with sequence similarity 198, member B
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FST follistatin
FSTL1 follistatin-like 1
GBP1 guanylate binding protein 1, interferon-inducible
GLO1 glyoxalase I
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HOPX HOP homeobox
HTRA1 HtrA serine peptidase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL2 lysyl oxidase-like 2
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MN1 meningioma (disrupted in balanced translocation) 1
MSN moesin
MT1F metallothionein 1F
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NELL2 NEL-like 2 (chicken)
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PAX6 paired box 6
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SEPT10 septin 10
SH3BGR SH3 domain binding glutamate-rich protein
SMYD3 SET and MYND domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SST somatostatin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TSPAN12 tetraspanin 12
UGP2 UDP-glucose pyrophosphorylase 2
VEGFA vascular endothelial growth factor A
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARF6 ADP-ribosylation factor 6
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
B3GNT1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP7 charged multivesicular body protein 7
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CSK c-src tyrosine kinase
CST3 cystatin C
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
ESR1 estrogen receptor 1
FA2H fatty acid 2-hydroxylase
FAM102A family with sequence similarity 102, member A
FOXA1 forkhead box A1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
FXYD2 FXYD domain containing ion transport regulator 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GEMIN4 gem (nuclear organelle) associated protein 4
GLS glutaminase
GOSR1 golgi SNAP receptor complex member 1
GRB2 growth factor receptor-bound protein 2
GRWD1 glutamate-rich WD repeat containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JADE2 jade family PHD finger 2
KAT7 K(lysine) acetyltransferase 7
KDM2A lysine (K)-specific demethylase 2A
KIF14 kinesin family member 14
KRT7 keratin 7, type II
KYNU kynureninase
LXN latexin
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MED1 mediator complex subunit 1
MED6 mediator complex subunit 6
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP7 matrix metallopeptidase 7
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NMD3 NMD3 ribosome export adaptor
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUPL1 nucleoporin like 1
OPN3 opsin 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PITRM1 pitrilysin metallopeptidase 1
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRKCD protein kinase C, delta
PRPF4 pre-mRNA processing factor 4
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSPC1 paraspeckle component 1
PTGES prostaglandin E synthase
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SDHAF1 succinate dehydrogenase complex assembly factor 1
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SIAH2 siah E3 ubiquitin protein ligase 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMG8 SMG8 nonsense mediated mRNA decay factor
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
STIL SCL/TAL1 interrupting locus
TACSTD2 tumor-associated calcium signal transducer 2
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDG thymine-DNA glycosylase
TFAM transcription factor A, mitochondrial
TFF1 trefoil factor 1
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM2D3 TM2 domain containing 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TRAF4 TNF receptor-associated factor 4
TRAPPC3 trafficking protein particle complex 3
TSKU tsukushi, small leucine rich proteoglycan
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VCPKMT valosin containing protein lysine (K) methyltransferase
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZBTB11 zinc finger and BTB domain containing 11
ZMYM2 zinc finger, MYM-type 2