BRD-K17953061_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K17953061_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ANGPTL2 angiopoietin-like 2
AQP8 aquaporin 8
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
CALCRL calcitonin receptor-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CD177 CD177 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CPM carboxypeptidase M
CREB1 cAMP responsive element binding protein 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CXADR coxsackie virus and adenovirus receptor
CXCL9 chemokine (C-X-C motif) ligand 9
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGLN3 egl-9 family hypoxia-inducible factor 3
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
EVI2A ecotropic viral integration site 2A
FAM198B family with sequence similarity 198, member B
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR3 fibroblast growth factor receptor 3
FHOD3 formin homology 2 domain containing 3
FN1 fibronectin 1
FPR3 formyl peptide receptor 3
FRZB frizzled-related protein
FZD6 frizzled class receptor 6
GALC galactosylceramidase
GCG glucagon
GNLY granulysin
GPER1 G protein-coupled estrogen receptor 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYPC glycophorin C (Gerbich blood group)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN4 high mobility group nucleosomal binding domain 4
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HTRA1 HtrA serine peptidase 1
IL2RB interleukin 2 receptor, beta
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDR kinase insert domain receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LPAR6 lysophosphatidic acid receptor 6
METTL21B methyltransferase like 21B
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MXRA5 matrix-remodelling associated 5
NID1 nidogen 1
NPTX2 neuronal pentraxin II
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PECAM1 platelet/endothelial cell adhesion molecule 1
PERP PERP, TP53 apoptosis effector
PKP2 plakophilin 2
PLBD1 phospholipase B domain containing 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCQ protein kinase C, theta
PRTN3 proteinase 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SELENBP1 selenium binding protein 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SST somatostatin
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRBC1 T cell receptor beta constant 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMDHD2 amidohydrolase domain containing 2
ANXA6 annexin A6
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BLVRA biliverdin reductase A
BST2 bone marrow stromal cell antigen 2
CASC3 cancer susceptibility candidate 3
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHSY1 chondroitin sulfate synthase 1
CYTH1 cytohesin 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EBP emopamil binding protein (sterol isomerase)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4A3 eukaryotic translation initiation factor 4A3
EMP3 epithelial membrane protein 3
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
GYG1 glycogenin 1
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
JADE1 jade family PHD finger 1
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LOX lysyl oxidase
MAPK6 mitogen-activated protein kinase 6
MET MET proto-oncogene, receptor tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS7 mitochondrial ribosomal protein S7
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NPC2 Niemann-Pick disease, type C2
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
OPN3 opsin 3
OXTR oxytocin receptor
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PRMT1 protein arginine methyltransferase 1
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RIT1 Ras-like without CAAX 1
RNMT RNA (guanine-7-) methyltransferase
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RRAGA Ras-related GTP binding A
S100A2 S100 calcium binding protein A2
SEPHS1 selenophosphate synthetase 1
SEPT9 septin 9
SERBP1 SERPINE1 mRNA binding protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SET SET nuclear proto-oncogene
SLC25A46 solute carrier family 25, member 46
SNRPE small nuclear ribonucleoprotein polypeptide E
SNUPN snurportin 1
SPDL1 spindle apparatus coiled-coil protein 1
SPRR3 small proline-rich protein 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRSF5 serine/arginine-rich splicing factor 5
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOMM34 translocase of outer mitochondrial membrane 34
TRAPPC3 trafficking protein particle complex 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
VGLL4 vestigial-like family member 4
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB38 zinc finger and BTB domain containing 38