BRD-K17953061_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K17953061_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT13 acyl-CoA thioesterase 13
ANXA4 annexin A4
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CEP70 centrosomal protein 70kDa
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC10A C-type lectin domain family 10, member A
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPM carboxypeptidase M
CRELD2 cysteine-rich with EGF-like domains 2
DCN decorin
EIF5A eukaryotic translation initiation factor 5A
EXPH5 exophilin 5
F11R F11 receptor
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
GAGE3 G antigen 3
GJA1 gap junction protein, alpha 1, 43kDa
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP5 insulin-like growth factor binding protein 5
ISYNA1 inositol-3-phosphate synthase 1
LOC100505650 uncharacterized LOC100505650
LPPR4 lipid phosphate phosphatase-related protein type 4
LTBP1 latent transforming growth factor beta binding protein 1
MMP9 matrix metallopeptidase 9
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
ORM1 orosomucoid 1
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RPL10 ribosomal protein L10
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC35F2 solute carrier family 35, member F2
SMYD3 SET and MYND domain containing 3
SNAP29 synaptosomal-associated protein, 29kDa
SOCS2 suppressor of cytokine signaling 2
SPINK1 serine peptidase inhibitor, Kazal type 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AFG3L2 AFG3-like AAA ATPase 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ASXL2 additional sex combs like transcriptional regulator 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C14ORF169 chromosome 14 open reading frame 169
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNA2 cyclin A2
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP170 centrosomal protein 170kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CLCN3 chloride channel, voltage-sensitive 3
CLTC clathrin, heavy chain (Hc)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS1 growth arrest-specific 1
GLS glutaminase
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GSTP1 glutathione S-transferase pi 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGF1R insulin-like growth factor 1 receptor
IL6ST interleukin 6 signal transducer
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KCTD12 potassium channel tetramerization domain containing 12
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KRT14 keratin 14, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAK16 MAK16 homolog (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MIA melanoma inhibitory activity
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYH10 myosin, heavy chain 10, non-muscle
NEK7 NIMA-related kinase 7
NRIP1 nuclear receptor interacting protein 1
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUP62 nucleoporin 62kDa
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
RAB14 RAB14, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM14 RNA binding motif protein 14
RGS2 regulator of G-protein signaling 2
RNF219 ring finger protein 219
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOAT1 sterol O-acyltransferase 1
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNM synemin, intermediate filament protein
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TGM2 transglutaminase 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TSPAN8 tetraspanin 8
TXNRD1 thioredoxin reductase 1
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
VGLL4 vestigial-like family member 4
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38
ZC3H13 zinc finger CCCH-type containing 13