BRD-K17896185_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

65 genes differentially expressed following the BRD-K17896185_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAST calpastatin
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EFNA1 ephrin-A1
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GRB10 growth factor receptor-bound protein 10
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
IDI1 isopentenyl-diphosphate delta isomerase 1
KDM5A lysine (K)-specific demethylase 5A
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
PERP PERP, TP53 apoptosis effector
RAB13 RAB13, member RAS oncogene family
RRAGC Ras-related GTP binding C
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SFRP4 secreted frizzled-related protein 4
SQLE squalene epoxidase
SUB1 SUB1 homolog (S. cerevisiae)
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
BCHE butyrylcholinesterase
CTSC cathepsin C
CTSH cathepsin H
DUSP22 dual specificity phosphatase 22
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
PHLDA1 pleckstrin homology-like domain, family A, member 1
PXMP2 peroxisomal membrane protein 2, 22kDa
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
THAP11 THAP domain containing 11
TSPAN7 tetraspanin 7
UGCG UDP-glucose ceramide glucosyltransferase