BRD-K17743697_KB-R7943 mesylate_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K17743697_KB-R7943 mesylate_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
ADIPOR2 adiponectin receptor 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF1 chromosome 14 open reading frame 1
CA12 carbonic anhydrase XII
CASP7 caspase 7, apoptosis-related cysteine peptidase
CETN2 centrin, EF-hand protein, 2
CST1 cystatin SN
CST3 cystatin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPP4 dipeptidyl-peptidase 4
EBP emopamil binding protein (sterol isomerase)
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FLRT3 fibronectin leucine rich transmembrane protein 3
FXYD2 FXYD domain containing ion transport regulator 2
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGED1 melanoma antigen family D1
MSMO1 methylsterol monooxygenase 1
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
PROS1 protein S (alpha)
PSAP prosaposin
RAP2A RAP2A, member of RAS oncogene family
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BZW2 basic leucine zipper and W2 domains 2
CALR calreticulin
COL3A1 collagen, type III, alpha 1
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
FRZB frizzled-related protein
FXYD5 FXYD domain containing ion transport regulator 5
HOXB2 homeobox B2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT7 keratin 7, type II
LMNB1 lamin B1
LOXL2 lysyl oxidase-like 2
MCM4 minichromosome maintenance complex component 4
MFAP2 microfibrillar-associated protein 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
OPHN1 oligophrenin 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PMP22 peripheral myelin protein 22
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SRGN serglycin
SRI sorcin
SULF1 sulfatase 1
TNIK TRAF2 and NCK interacting kinase
XIST X inactive specific transcript (non-protein coding)