BRD-K17743697_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

30 genes differentially expressed following the BRD-K17743697_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
CLU clusterin
DHCR7 7-dehydrocholesterol reductase
EFNB2 ephrin-B2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
SQLE squalene epoxidase
TRAPPC3 trafficking protein particle complex 3
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AREG amphiregulin
EDNRB endothelin receptor type B
EGR1 early growth response 1
HBB hemoglobin, beta
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
KANK1 KN motif and ankyrin repeat domains 1
LXN latexin
PPAP2B phosphatidic acid phosphatase type 2B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
SNAI2 snail family zinc finger 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TUBB2B tubulin, beta 2B class IIb