BRD-K17743125_belinostat_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

240 genes differentially expressed following the BRD-K17743125_belinostat_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM10 ADAM metallopeptidase domain 10
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANGPT1 angiopoietin 1
ANXA3 annexin A3
ARF3 ADP-ribosylation factor 3
ARHGAP29 Rho GTPase activating protein 29
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BCL3 B-cell CLL/lymphoma 3
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD2L C2CD2-like
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CCND3 cyclin D3
CCNG2 cyclin G2
CD24 CD24 molecule
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CETN2 centrin, EF-hand protein, 2
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DCTN3 dynactin 3 (p22)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUSP5 dual specificity phosphatase 5
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
ELOVL5 ELOVL fatty acid elongase 5
ETNK1 ethanolamine kinase 1
EZR ezrin
FAM117A family with sequence similarity 117, member A
FAM171A1 family with sequence similarity 171, member A1
FAR2 fatty acyl CoA reductase 2
FLNA filamin A, alpha
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
GRWD1 glutamate-rich WD repeat containing 1
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HIST1H4H histone cluster 1, H4h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0040 KIAA0040
KIF5C kinesin family member 5C
LCN2 lipocalin 2
LGALS4 lectin, galactoside-binding, soluble, 4
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LRRC16A leucine rich repeat containing 16A
LSR lipolysis stimulated lipoprotein receptor
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MIR22HG MIR22 host gene
NCAM1 neural cell adhesion molecule 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELFE negative elongation factor complex member E
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NRCAM neuronal cell adhesion molecule
NUP98 nucleoporin 98kDa
OLFM4 olfactomedin 4
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PALLD palladin, cytoskeletal associated protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PROM1 prominin 1
PRSS3 protease, serine, 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBP4 retinol binding protein 4, plasma
REG1B regenerating islet-derived 1 beta
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPHS2 selenophosphate synthetase 2
SGCE sarcoglycan, epsilon
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLIT2 slit homolog 2 (Drosophila)
SORBS1 sorbin and SH3 domain containing 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
STK26 serine/threonine protein kinase 26
STX3 syntaxin 3
STXBP1 syntaxin binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAC1 tachykinin, precursor 1
TBX3 T-box 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM100 transmembrane protein 100
TMSB15A thymosin beta 15a
TNC tenascin C
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VNN1 vanin 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACOX2 acyl-CoA oxidase 2, branched chain
ADCY3 adenylate cyclase 3
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
APLP2 amyloid beta (A4) precursor-like protein 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
CA12 carbonic anhydrase XII
CALR calreticulin
CCNB2 cyclin B2
CCNE2 cyclin E2
CFH complement factor H
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COMT catechol-O-methyltransferase
COPS7A COP9 signalosome subunit 7A
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EPCAM epithelial cell adhesion molecule
EPN2 epsin 2
EREG epiregulin
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOLR1 folate receptor 1 (adult)
GAMT guanidinoacetate N-methyltransferase
GPX1 glutathione peroxidase 1
GTF3A general transcription factor IIIA
GUSBP11 glucuronidase, beta pseudogene 11
HDDC2 HD domain containing 2
HMGA2 high mobility group AT-hook 2
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
LOXL1 lysyl oxidase-like 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MLPH melanophilin
MRPS2 mitochondrial ribosomal protein S2
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
N4BP2L2 NEDD4 binding protein 2-like 2
NNT nicotinamide nucleotide transhydrogenase
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPAP2C phosphatidic acid phosphatase type 2C
PPIC peptidylprolyl isomerase C (cyclophilin C)
PTK2 protein tyrosine kinase 2
S100A4 S100 calcium binding protein A4
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SLC2A4RG SLC2A4 regulator
SLC35F2 solute carrier family 35, member F2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF7 serine/arginine-rich splicing factor 7
STEAP3 STEAP family member 3, metalloreductase
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TEAD4 TEA domain family member 4
TFDP1 transcription factor Dp-1
TNNC1 troponin C type 1 (slow)
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
YBX3 Y box binding protein 3
ZBTB38 zinc finger and BTB domain containing 38
ZMYM2 zinc finger, MYM-type 2