BRD-K17743125_belinostat_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K17743125_belinostat_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ARF3 ADP-ribosylation factor 3
ARG1 arginase 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BPGM 2,3-bisphosphoglycerate mutase
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CLCA2 chloride channel accessory 2
CPM carboxypeptidase M
EFNB2 ephrin-B2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
INHBA inhibin, beta A
LEF1 lymphoid enhancer-binding factor 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MBD4 methyl-CpG binding domain protein 4
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSRB1 methionine sulfoxide reductase B1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NRCAM neuronal cell adhesion molecule
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNRC1 proline-rich nuclear receptor coactivator 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAP2A RAP2A, member of RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
SC5D sterol-C5-desaturase
SELL selectin L
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
VWA5A von Willebrand factor A domain containing 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
COPS7A COP9 signalosome subunit 7A
CXCL5 chemokine (C-X-C motif) ligand 5
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGL immunoglobulin lambda locus
KIF14 kinesin family member 14
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
PDLIM1 PDZ and LIM domain 1
PGAP3 post-GPI attachment to proteins 3
PMP22 peripheral myelin protein 22
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
REEP5 receptor accessory protein 5
RNH1 ribonuclease/angiogenin inhibitor 1
S100A2 S100 calcium binding protein A2
SAP18 Sin3A-associated protein, 18kDa
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
ZMYM2 zinc finger, MYM-type 2