BRD-K17743125_belinostat_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-K17743125_belinostat_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
BCL3 B-cell CLL/lymphoma 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CALB1 calbindin 1, 28kDa
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFD complement factor D (adipsin)
CIB1 calcium and integrin binding 1 (calmyrin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
COL14A1 collagen, type XIV, alpha 1
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTSC cathepsin C
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DMBT1 deleted in malignant brain tumors 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK4 docking protein 4
ECI2 enoyl-CoA delta isomerase 2
EDNRA endothelin receptor type A
EFHD1 EF-hand domain family, member D1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EVL Enah/Vasp-like
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FBLN5 fibulin 5
FCGBP Fc fragment of IgG binding protein
FLNA filamin A, alpha
FN1 fibronectin 1
FOXC1 forkhead box C1
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GCC2 GRIP and coiled-coil domain containing 2
GLO1 glyoxalase I
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEBP1 heme binding protein 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXA11 homeobox A11
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
JARID2 jumonji, AT rich interactive domain 2
JUND jun D proto-oncogene
KIF5C kinesin family member 5C
KPNA6 karyopherin alpha 6 (importin alpha 7)
KRT19 keratin 19, type I
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC16A leucine rich repeat containing 16A
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKSL1 MARCKS-like 1
MMD monocyte to macrophage differentiation-associated
MUC1 mucin 1, cell surface associated
MVP major vault protein
MYH11 myosin, heavy chain 11, smooth muscle
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMT2 N-myristoyltransferase 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSR2 odd-skipped related transciption factor 2
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKM pyruvate kinase, muscle
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PRAF2 PRA1 domain family, member 2
PRKCZ protein kinase C, zeta
PRSS8 protease, serine, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM47 RNA binding motif protein 47
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN2 reticulon 2
S100A11 S100 calcium binding protein A11
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SIX1 SIX homeobox 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOBP sine oculis binding protein homolog (Drosophila)
SQSTM1 sequestosome 1
SRGN serglycin
STOM stomatin
STX1A syntaxin 1A (brain)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT1 synaptotagmin I
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRIM33 tripartite motif containing 33
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VAT1 vesicle amine transport 1
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BLNK B-cell linker
BTG3 BTG family, member 3
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CDK14 cyclin-dependent kinase 14
CHEK1 checkpoint kinase 1
COL5A2 collagen, type V, alpha 2
COPS7A COP9 signalosome subunit 7A
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DUSP2 dual specificity phosphatase 2
DUT deoxyuridine triphosphatase
EIF4A1 eukaryotic translation initiation factor 4A1
FKBP11 FK506 binding protein 11, 19 kDa
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
GTPBP8 GTP-binding protein 8 (putative)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BK histone cluster 1, H2bk
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
IFRD2 interferon-related developmental regulator 2
ING3 inhibitor of growth family, member 3
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIF15 kinesin family member 15
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MPDU1 mannose-P-dolichol utilization defect 1
MSRA methionine sulfoxide reductase A
NCAPG non-SMC condensin I complex, subunit G
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
ODC1 ornithine decarboxylase 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCBP2 poly(rC) binding protein 2
PCNA proliferating cell nuclear antigen
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR1 phospholipid scramblase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PTS 6-pyruvoyltetrahydropterin synthase
RPL10 ribosomal protein L10
RSRP1 arginine/serine-rich protein 1
SLC35A5 solute carrier family 35, member A5
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SPAG7 sperm associated antigen 7
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF7 serine/arginine-rich splicing factor 7
SULF1 sulfatase 1
TFR2 transferrin receptor 2
THBS2 thrombospondin 2
TIMELESS timeless circadian clock
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
YME1L1 YME1-like 1 ATPase
ZBTB38 zinc finger and BTB domain containing 38
ZWINT ZW10 interacting kinetochore protein