BRD-K17743125_belinostat_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K17743125_belinostat_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ARG1 arginase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CORO1A coronin, actin binding protein, 1A
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
EPHB2 EPH receptor B2
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBN2 fibrillin 2
FNBP1L formin binding protein 1-like
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
HOPX HOP homeobox
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
JAM2 junctional adhesion molecule 2
KLF2 Kruppel-like factor 2
LCN2 lipocalin 2
LPCAT1 lysophosphatidylcholine acyltransferase 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP2 microfibrillar-associated protein 2
MVP major vault protein
PLA2G16 phospholipase A2, group XVI
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKCH protein kinase C, eta
RHOB ras homolog family member B
RUNX1 runt-related transcription factor 1
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
STC1 stanniocalcin 1
TCF4 transcription factor 4
THBS4 thrombospondin 4
TLE4 transducin-like enhancer of split 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
CCNA2 cyclin A2
CPE carboxypeptidase E
CRELD2 cysteine-rich with EGF-like domains 2
CTSB cathepsin B
CTSH cathepsin H
CXADR coxsackie virus and adenovirus receptor
DEK DEK proto-oncogene
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNM1L dynamin 1-like
FOLR1 folate receptor 1 (adult)
GDF15 growth differentiation factor 15
GTPBP8 GTP-binding protein 8 (putative)
HOXB2 homeobox B2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF14 kinesin family member 14
LGALS2 lectin, galactoside-binding, soluble, 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL7A methyltransferase like 7A
MSMB microseminoprotein, beta-
NPTXR neuronal pentraxin receptor
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PEG10 paternally expressed 10
PRPF4 pre-mRNA processing factor 4
RAD51C RAD51 paralog C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS3 transmembrane protease, serine 3
TSC22D1 TSC22 domain family, member 1