BRD-K17743125_belinostat_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K17743125_belinostat_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ANXA3 annexin A3
AREG amphiregulin
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CETN2 centrin, EF-hand protein, 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COBL cordon-bleu WH2 repeat protein
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
DHDDS dehydrodolichyl diphosphate synthase
DUSP6 dual specificity phosphatase 6
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXO4 forkhead box O4
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC3 glypican 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMG20B high mobility group 20B
IFI16 interferon, gamma-inducible protein 16
IFI44L interferon-induced protein 44-like
IFNGR1 interferon gamma receptor 1
IGF1R insulin-like growth factor 1 receptor
IRF8 interferon regulatory factor 8
ISOC1 isochorismatase domain containing 1
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LIPA lipase A, lysosomal acid, cholesterol esterase
LRP10 low density lipoprotein receptor-related protein 10
LTB lymphotoxin beta (TNF superfamily, member 3)
LY6E lymphocyte antigen 6 complex, locus E
LYN LYN proto-oncogene, Src family tyrosine kinase
MEGF9 multiple EGF-like-domains 9
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NEBL nebulette
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
PLLP plasmolipin
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
STK17A serine/threonine kinase 17a
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TSPYL5 TSPY-like 5
TXN thioredoxin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
C2CD5 C2 calcium-dependent domain containing 5
CDC25B cell division cycle 25B
CNR1 cannabinoid receptor 1 (brain)
CRISP3 cysteine-rich secretory protein 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM129A family with sequence similarity 129, member A
FGB fibrinogen beta chain
FRZB frizzled-related protein
GEM GTP binding protein overexpressed in skeletal muscle
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
IPO13 importin 13
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KRT13 keratin 13, type I
PCP4 Purkinje cell protein 4
PPIC peptidylprolyl isomerase C (cyclophilin C)
SEPP1 selenoprotein P, plasma, 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TUG1 taurine up-regulated 1 (non-protein coding)
TWIST1 twist family bHLH transcription factor 1
UBE2C ubiquitin-conjugating enzyme E2C