BRD-K17743125_belinostat_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K17743125_belinostat_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADK adenosine kinase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
AQP1 aquaporin 1 (Colton blood group)
ARMCX6 armadillo repeat containing, X-linked 6
ASMTL acetylserotonin O-methyltransferase-like
CCNG2 cyclin G2
CD24 CD24 molecule
CDA cytidine deaminase
CFD complement factor D (adipsin)
CHIC2 cysteine-rich hydrophobic domain 2
CHPT1 choline phosphotransferase 1
CLIC3 chloride intracellular channel 3
CTSD cathepsin D
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DMTF1 cyclin D binding myb-like transcription factor 1
DPP4 dipeptidyl-peptidase 4
DPYSL2 dihydropyrimidinase-like 2
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6B glycoprotein M6B
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HSBP1 heat shock factor binding protein 1
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFT20 intraflagellar transport 20
INHBA inhibin, beta A
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
KLF6 Kruppel-like factor 6
LEF1 lymphoid enhancer-binding factor 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
METRN meteorin, glial cell differentiation regulator
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSX1 msh homeobox 1
MX1 MX dynamin-like GTPase 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCDH9 protocadherin 9
PNMA2 paraneoplastic Ma antigen 2
PRAF2 PRA1 domain family, member 2
PTBP2 polypyrimidine tract binding protein 2
PTTG1IP pituitary tumor-transforming 1 interacting protein
PVRL3 poliovirus receptor-related 3
RABAC1 Rab acceptor 1 (prenylated)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
SALL1 spalt-like transcription factor 1
SEPP1 selenoprotein P, plasma, 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC46A3 solute carrier family 46, member 3
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPP1 tripeptidyl peptidase I
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
WRB tryptophan rich basic protein

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AUTS2 autism susceptibility candidate 2
CAPN1 calpain 1, (mu/I) large subunit
CCL2 chemokine (C-C motif) ligand 2
CEP55 centrosomal protein 55kDa
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DPT dermatopontin
EFS embryonal Fyn-associated substrate
EHF ets homologous factor
EIF4A1 eukaryotic translation initiation factor 4A1
EPHA3 EPH receptor A3
GPX1 glutathione peroxidase 1
GTPBP8 GTP-binding protein 8 (putative)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB2 high mobility group box 2
HOXB6 homeobox B6
IDO1 indoleamine 2,3-dioxygenase 1
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
M6PR mannose-6-phosphate receptor (cation dependent)
MBP myelin basic protein
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
NLRP2 NLR family, pyrin domain containing 2
PDE4B phosphodiesterase 4B, cAMP-specific
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
RPL10 ribosomal protein L10
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
SELL selectin L
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFRC transferrin receptor
TIMELESS timeless circadian clock
TMEM5 transmembrane protein 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TRIM29 tripartite motif containing 29
TRIP6 thyroid hormone receptor interactor 6
VTCN1 V-set domain containing T cell activation inhibitor 1
ZMYND11 zinc finger, MYND-type containing 11