BRD-K17743125_belinostat_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-K17743125_belinostat_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADIRF adipogenesis regulatory factor
AQP1 aquaporin 1 (Colton blood group)
AUTS2 autism susceptibility candidate 2
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CPA3 carboxypeptidase A3 (mast cell)
CTSC cathepsin C
CYBA cytochrome b-245, alpha polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FBLN5 fibulin 5
FOXF1 forkhead box F1
GATA6 GATA binding protein 6
GPC3 glypican 3
GREM1 gremlin 1, DAN family BMP antagonist
IL6ST interleukin 6 signal transducer
MAP1B microtubule-associated protein 1B
MMD monocyte to macrophage differentiation-associated
MVP major vault protein
NEBL nebulette
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSBPL10 oxysterol binding protein-like 10
PEG10 paternally expressed 10
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
QPRT quinolinate phosphoribosyltransferase
RPA3 replication protein A3, 14kDa
S100A11 S100 calcium binding protein A11
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD3 SMAD family member 3
STAR steroidogenic acute regulatory protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOB2 transducer of ERBB2, 2
TOX3 TOX high mobility group box family member 3
TSPAN13 tetraspanin 13
TTN titin
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARG2 arginase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EPHA3 EPH receptor A3
FKBP1B FK506 binding protein 1B, 12.6 kDa
GTPBP8 GTP-binding protein 8 (putative)
HCAR3 hydroxycarboxylic acid receptor 3
IL6R interleukin 6 receptor
KLF11 Kruppel-like factor 11
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
LIG1 ligase I, DNA, ATP-dependent
MAGEA4 melanoma antigen family A4
MEOX2 mesenchyme homeobox 2
ODC1 ornithine decarboxylase 1
RORA RAR-related orphan receptor A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SORBS3 sorbin and SH3 domain containing 3
TP53 tumor protein p53
ZMYM2 zinc finger, MYM-type 2