BRD-K17561142_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K17561142_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD11 ankyrin repeat domain 11
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BMP2 bone morphogenetic protein 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
COL6A2 collagen, type VI, alpha 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETV5 ets variant 5
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GLG1 golgi glycoprotein 1
GRB10 growth factor receptor-bound protein 10
GTPBP1 GTP binding protein 1
H1F0 H1 histone family, member 0
HCAR3 hydroxycarboxylic acid receptor 3
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA1598
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NLGN4X neuroligin 4, X-linked
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PER1 period circadian clock 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PSD3 pleckstrin and Sec7 domain containing 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNMT RNA (guanine-7-) methyltransferase
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM87A transmembrane protein 87A
UBXN7 UBX domain protein 7
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF131 zinc finger protein 131
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AQP1 aquaporin 1 (Colton blood group)
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CD36 CD36 molecule (thrombospondin receptor)
CETN2 centrin, EF-hand protein, 2
CTSC cathepsin C
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FHL1 four and a half LIM domains 1
GLO1 glyoxalase I
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSTA4 glutathione S-transferase alpha 4
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP7 insulin-like growth factor binding protein 7
LRRN3 leucine rich repeat neuronal 3
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAT2A methionine adenosyltransferase II, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NT5DC2 5'-nucleotidase domain containing 2
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TSPAN13 tetraspanin 13
TXNDC9 thioredoxin domain containing 9
XIST X inactive specific transcript (non-protein coding)