BRD-K17497770_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K17497770_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASS1 argininosuccinate synthase 1
CCDC86 coiled-coil domain containing 86
CDKN2A cyclin-dependent kinase inhibitor 2A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
NRCAM neuronal cell adhesion molecule
NUCB2 nucleobindin 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
RGCC regulator of cell cycle
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SHB Src homology 2 domain containing adaptor protein B
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SUSD4 sushi domain containing 4
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CDK6 cyclin-dependent kinase 6
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLC1 DLC1 Rho GTPase activating protein
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPCAM epithelial cell adhesion molecule
EVL Enah/Vasp-like
FERMT2 fermitin family member 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
KRT19 keratin 19, type I
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDGFC platelet derived growth factor C
PLS1 plastin 1
STK26 serine/threonine protein kinase 26
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C
WFDC2 WAP four-disulfide core domain 2