BRD-K17497770_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K17497770_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CD44 CD44 molecule (Indian blood group)
CDK14 cyclin-dependent kinase 14
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCN3 chloride channel, voltage-sensitive 3
COL11A1 collagen, type XI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
COPS7A COP9 signalosome subunit 7A
CSRP2 cysteine and glycine-rich protein 2
DIO2 deiodinase, iodothyronine, type II
DLX5 distal-less homeobox 5
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F11R F11 receptor
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GAS6 growth arrest-specific 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIC2 hypermethylated in cancer 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IQCG IQ motif containing G
ISG20 interferon stimulated exonuclease gene 20kDa
ITPKB inositol-trisphosphate 3-kinase B
KDM3A lysine (K)-specific demethylase 3A
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LOC100505650 uncharacterized LOC100505650
LOXL2 lysyl oxidase-like 2
LYPD3 LY6/PLAUR domain containing 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
NDRG1 N-myc downstream regulated 1
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
PGK1 phosphoglycerate kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRAME preferentially expressed antigen in melanoma
RBM38 RNA binding motif protein 38
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNMT RNA (guanine-7-) methyltransferase
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMT1 acidic residue methyltransferase 1
C7 complement component 7
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
GRB14 growth factor receptor-bound protein 14
HEATR1 HEAT repeat containing 1
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HN1 hematological and neurological expressed 1
IFITM3 interferon induced transmembrane protein 3
IGFBP1 insulin-like growth factor binding protein 1
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYZ lysozyme
NFIB nuclear factor I/B
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
RELN reelin
RGS5 regulator of G-protein signaling 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C