BRD-K17140735_-666_VCAP_24.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K17140735_-666_VCAP_24.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ADIPOR1 adiponectin receptor 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
C14ORF1 chromosome 14 open reading frame 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC4 chloride intracellular channel 4
COLEC12 collectin sub-family member 12
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
ENO2 enolase 2 (gamma, neuronal)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM134B family with sequence similarity 134, member B
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FRY furry homolog (Drosophila)
GDI1 GDP dissociation inhibitor 1
GLUL glutamate-ammonia ligase
GSTA4 glutathione S-transferase alpha 4
GUSBP3 glucuronidase, beta pseudogene 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
KIAA0226L KIAA0226-like
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NPIPB3 nuclear pore complex interacting protein family, member B3
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
TMEM97 transmembrane protein 97
TPD52 tumor protein D52
TPM4 tropomyosin 4
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW2 basic leucine zipper and W2 domains 2
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDCA8 cell division cycle associated 8
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CKS2 CDC28 protein kinase regulatory subunit 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBNA1BP2 EBNA1 binding protein 2
EIF5B eukaryotic translation initiation factor 5B
FBLN5 fibulin 5
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP8 GTP-binding protein 8 (putative)
GTSE1 G-2 and S-phase expressed 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BE histone cluster 1, H2be
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
MKI67 marker of proliferation Ki-67
MXRA8 matrix-remodelling associated 8
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NPY1R neuropeptide Y receptor Y1
NUP93 nucleoporin 93kDa
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLS3 plastin 3
PRDX4 peroxiredoxin 4
PRKCB protein kinase C, beta
PTTG1 pituitary tumor-transforming 1
PWP1 PWP1 homolog (S. cerevisiae)
RCC1 regulator of chromosome condensation 1
SPARCL1 SPARC-like 1 (hevin)
SPDL1 spindle apparatus coiled-coil protein 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPYL5 TSPY-like 5
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S