BRD-K17140735_-666_SW620_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K17140735_-666_SW620_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CCNG2 cyclin G2
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLCA4 chloride channel accessory 4
CLDN4 claudin 4
CTH cystathionine gamma-lyase
CTSK cathepsin K
CTSS cathepsin S
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSG3 desmoglein 3
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
EZR ezrin
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUP junction plakoglobin
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT1 keratin 1, type II
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KTN1 kinectin 1 (kinesin receptor)
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LIMA1 LIM domain and actin binding 1
LUM lumican
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MICALL1 MICAL-like 1
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
OPTN optineurin
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAIP1 poly(A) binding protein interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS23 protease, serine, 23
PTN pleiotrophin
RAB9A RAB9A, member RAS oncogene family
RBPMS RNA binding protein with multiple splicing
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
S100A13 S100 calcium binding protein A13
S100A14 S100 calcium binding protein A14
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SELE selectin E
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SIK1 salt-inducible kinase 1
SPON2 spondin 2, extracellular matrix protein
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SQSTM1 sequestosome 1
TAGLN2 transgelin 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TUFT1 tuftelin 1
UBE3C ubiquitin protein ligase E3C
UPP1 uridine phosphorylase 1
VCL vinculin
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASRGL1 asparaginase like 1
B3GNT1
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCP110 centriolar coiled coil protein 110kDa
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CES1 carboxylesterase 1
CIRBP cold inducible RNA binding protein
COL2A1 collagen, type II, alpha 1
CPE carboxypeptidase E
CTSG cathepsin G
CTSH cathepsin H
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
CYTL1 cytokine-like 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP10 FK506 binding protein 10, 65 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKBP5 FK506 binding protein 5
FRZB frizzled-related protein
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPC3 glypican 3
GPX7 glutathione peroxidase 7
GRWD1 glutamate-rich WD repeat containing 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1R2 interleukin 1 receptor, type II
KCTD12 potassium channel tetramerization domain containing 12
KIAA0485 uncharacterized LOC57235
LAMP5 lysosomal-associated membrane protein family, member 5
LCMT2 leucine carboxyl methyltransferase 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC283683 uncharacterized LOC283683
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY86 lymphocyte antigen 86
LYZ lysozyme
MAPK13 mitogen-activated protein kinase 13
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MYB v-myb avian myeloblastosis viral oncogene homolog
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PCDH9 protocadherin 9
PDIA3 protein disulfide isomerase family A, member 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PTDSS1 phosphatidylserine synthase 1
PTMA prothymosin, alpha
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PXMP2 peroxisomal membrane protein 2, 22kDa
RETN resistin
RNASET2 ribonuclease T2
RPA3 replication protein A3, 14kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX2 SRY (sex determining region Y)-box 2
SRSF6 serine/arginine-rich splicing factor 6
STEAP3 STEAP family member 3, metalloreductase
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THAP11 THAP domain containing 11
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TOR1A torsin family 1, member A (torsin A)
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WIF1 WNT inhibitory factor 1