BRD-K17140735_-666_HT29_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

321 genes differentially expressed following the BRD-K17140735_-666_HT29_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
ACKR3 atypical chemokine receptor 3
AKAP13 A kinase (PRKA) anchor protein 13
ANXA1 annexin A1
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAPN2 calpain 2, (m/II) large subunit
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRY1 cryptochrome circadian clock 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYTH1 cytohesin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND5A DENN/MADD domain containing 5A
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMP1 epithelial membrane protein 1
EREG epiregulin
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1A interleukin 1, alpha
IL6ST interleukin 6 signal transducer
ILK integrin-linked kinase
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IQCG IQ motif containing G
IRF1 interferon regulatory factor 1
IRF6 interferon regulatory factor 6
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITCH itchy E3 ubiquitin protein ligase
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPKC inositol-trisphosphate 3-kinase C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM6B lysine (K)-specific demethylase 6B
KIAA0355 KIAA0355
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP7D1 MAP7 domain containing 1
MAPK6 mitogen-activated protein kinase 6
MCL1 myeloid cell leukemia 1
MED8 mediator complex subunit 8
MFAP5 microfibrillar associated protein 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MSX1 msh homeobox 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MT2A metallothionein 2A
NAMPT nicotinamide phosphoribosyltransferase
NDEL1 nudE neurodevelopment protein 1-like 1
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPC1 Niemann-Pick disease, type C1
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEA15 phosphoprotein enriched in astrocytes 15
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRNP prion protein
PSEN1 presenilin 1
PTN pleiotrophin
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
RAB9A RAB9A, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RB1CC1 RB1-inducible coiled-coil 1
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
RHOB ras homolog family member B
RHOC ras homolog family member C
RIOK3 RIO kinase 3
RIPK2 receptor-interacting serine-threonine kinase 2
RIT1 Ras-like without CAAX 1
RND1 Rho family GTPase 1
RNF19B ring finger protein 19B
RRAD Ras-related associated with diabetes
RRAGC Ras-related GTP binding C
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SEC24A SEC24 family member A
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPEN spen family transcriptional repressor
STK17A serine/threonine kinase 17a
STX12 syntaxin 12
STX1A syntaxin 1A (brain)
TES testin LIM domain protein
TFE3 transcription factor binding to IGHM enhancer 3
TICAM1 toll-like receptor adaptor molecule 1
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM41B transmembrane protein 41B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIP1 TNFAIP3 interacting protein 1
TOB2 transducer of ERBB2, 2
TP53BP2 tumor protein p53 binding protein 2
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSPAN1 tetraspanin 1
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZC3H12A zinc finger CCCH-type containing 12A

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATP10B ATPase, class V, type 10B
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
AURKA aurora kinase A
B3GNT1
BCHE butyrylcholinesterase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DACH1 dachshund family transcription factor 1
DEFA5 defensin, alpha 5, Paneth cell-specific
DEFA6 defensin, alpha 6, Paneth cell-specific
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
EDNRB endothelin receptor type B
F12 coagulation factor XII (Hageman factor)
FABP1 fatty acid binding protein 1, liver
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
GEMIN6 gem (nuclear organelle) associated protein 6
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GRWD1 glutamate-rich WD repeat containing 1
HMGN3 high mobility group nucleosomal binding domain 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KIAA0485 uncharacterized LOC57235
LIG1 ligase I, DNA, ATP-dependent
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MMP12 matrix metallopeptidase 12
MRPL16 mitochondrial ribosomal protein L16
MRPL35 mitochondrial ribosomal protein L35
MYB v-myb avian myeloblastosis viral oncogene homolog
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOP16 NOP16 nucleolar protein
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
ORC5 origin recognition complex, subunit 5
PBX1 pre-B-cell leukemia homeobox 1
PFKM phosphofructokinase, muscle
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PON2 paraoxonase 2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPA2 pyrophosphatase (inorganic) 2
PPIH peptidylprolyl isomerase H (cyclophilin H)
REG3A regenerating islet-derived 3 alpha
RFC3 replication factor C (activator 1) 3, 38kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
RRP1B ribosomal RNA processing 1B
S100A8 S100 calcium binding protein A8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF7 serine/arginine-rich splicing factor 7
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM109 transmembrane protein 109
TRIM14 tripartite motif containing 14
TRMT61B tRNA methyltransferase 61B
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12
TYRP1 tyrosinase-related protein 1
UNG uracil-DNA glycosylase
ZNF544 zinc finger protein 544