BRD-K17140735_-666_A375_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K17140735_-666_A375_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARID5B AT rich interactive domain 5B (MRF1-like)
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CALD1 caldesmon 1
CCL5 chemokine (C-C motif) ligand 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
CRABP2 cellular retinoic acid binding protein 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP8 dual specificity phosphatase 8
EFNA1 ephrin-A1
EGR1 early growth response 1
FAM69A family with sequence similarity 69, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-E major histocompatibility complex, class I, E
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KRT6B keratin 6B, type II
LGALS8 lectin, galactoside-binding, soluble, 8
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MTSS1 metastasis suppressor 1
N4BP1 NEDD4 binding protein 1
NDRG1 N-myc downstream regulated 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXN nucleoredoxin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDLIM3 PDZ and LIM domain 3
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RAD21 RAD21 homolog (S. pombe)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RLF rearranged L-myc fusion
RSRC2 arginine/serine-rich coiled-coil 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SOD2 superoxide dismutase 2, mitochondrial
SPRED2 sprouty-related, EVH1 domain containing 2
SQLE squalene epoxidase
TCF4 transcription factor 4
TLK2 tousled-like kinase 2
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ARMT1 acidic residue methyltransferase 1
AURKA aurora kinase A
CCND2 cyclin D2
CCNF cyclin F
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CHMP6 charged multivesicular body protein 6
CIRBP cold inducible RNA binding protein
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM111A family with sequence similarity 111, member A
GMDS GDP-mannose 4,6-dehydratase
IGF1R insulin-like growth factor 1 receptor
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMO2 LIM domain only 2 (rhombotin-like 1)
MKI67 marker of proliferation Ki-67
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
QDPR quinoid dihydropteridine reductase
RPS11 ribosomal protein S11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM47 transmembrane protein 47
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5