BRD-K17086338_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K17086338_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AREG amphiregulin
BMP2 bone morphogenetic protein 2
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IL1RL1 interleukin 1 receptor-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NES nestin
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOD2 superoxide dismutase 2, mitochondrial
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STK39 serine threonine kinase 39
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
VNN1 vanin 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ANKRD10 ankyrin repeat domain 10
ATF5 activating transcription factor 5
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CAST calpastatin
CD36 CD36 molecule (thrombospondin receptor)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CHMP4A charged multivesicular body protein 4A
CIAPIN1 cytokine induced apoptosis inhibitor 1
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EVI2B ecotropic viral integration site 2B
FAM13A family with sequence similarity 13, member A
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GPER1 G protein-coupled estrogen receptor 1
HBB hemoglobin, beta
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGN3 high mobility group nucleosomal binding domain 3
HOXB7 homeobox B7
HOXC6 homeobox C6
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
METTL3 methyltransferase like 3
MUC16 mucin 16, cell surface associated
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PARP2 poly (ADP-ribose) polymerase 2
PDZK1 PDZ domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PROM1 prominin 1
REEP5 receptor accessory protein 5
SCGB2A1 secretoglobin, family 2A, member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
ZNF586 zinc finger protein 586