BRD-K17075857_Chloroxine_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K17075857_Chloroxine_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADD3 adducin 3 (gamma)
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C6ORF48 chromosome 6 open reading frame 48
CA2 carbonic anhydrase II
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD52 CD52 molecule
CDC25B cell division cycle 25B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOCK9 dedicator of cytokinesis 9
DSP desmoplakin
ECM1 extracellular matrix protein 1
EPAS1 endothelial PAS domain protein 1
FN1 fibronectin 1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IL6 interleukin 6
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KRT6B keratin 6B, type II
KYNU kynureninase
LXN latexin
MAL mal, T-cell differentiation protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
RND3 Rho family GTPase 3
SARS seryl-tRNA synthetase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SRGN serglycin
STC2 stanniocalcin 2
TBXA2R thromboxane A2 receptor
THBS2 thrombospondin 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB3 tribbles pseudokinase 3
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CHRDL1 chordin-like 1
CORO1A coronin, actin binding protein, 1A
CSRP2 cysteine and glycine-rich protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HN1 hematological and neurological expressed 1
HSPA2 heat shock 70kDa protein 2
IGHD immunoglobulin heavy constant delta
IGLV3-19 immunoglobulin lambda variable 3-19
LAPTM4B lysosomal protein transmembrane 4 beta
PLAC8 placenta-specific 8
PUF60 poly-U binding splicing factor 60KDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
STIP1 stress-induced phosphoprotein 1
TAGLN2 transgelin 2
TSPAN8 tetraspanin 8
ZW10 zw10 kinetochore protein