BRD-K17075857_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K17075857_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP9 aquaporin 9
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CA2 carbonic anhydrase II
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CERS6 ceramide synthase 6
DDIT4 DNA-damage-inducible transcript 4
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
JAG1 jagged 1
LARP6 La ribonucleoprotein domain family, member 6
LY96 lymphocyte antigen 96
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUPR1 nuclear protein, transcriptional regulator, 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SHB Src homology 2 domain containing adaptor protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TAGLN transgelin
TBX3 T-box 3
THBS1 thrombospondin 1
TMEM176B transmembrane protein 176B
TSC22D1 TSC22 domain family, member 1
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTB actin, beta
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IFITM2 interferon induced transmembrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
MXRA5 matrix-remodelling associated 5
PTCH1 patched 1
RPS11 ribosomal protein S11
SCEL sciellin
TSPAN8 tetraspanin 8
TUBB4B tubulin, beta 4B class IVb