BRD-K16621777_S1174_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K16621777_S1174_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
ANPEP alanyl (membrane) aminopeptidase
ARFIP2 ADP-ribosylation factor interacting protein 2
ATF5 activating transcription factor 5
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIK BCL2-interacting killer (apoptosis-inducing)
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COBL cordon-bleu WH2 repeat protein
COL9A3 collagen, type IX, alpha 3
CSRP1 cysteine and glycine-rich protein 1
CTSB cathepsin B
CUX2 cut-like homeobox 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R1 cytochrome b5 reductase 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GLRX glutaredoxin (thioltransferase)
H1F0 H1 histone family, member 0
HOMER2 homer scaffolding protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
LDLR low density lipoprotein receptor
LGMN legumain
LIMK2 LIM domain kinase 2
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
MYBPC1 myosin binding protein C, slow type
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NPC2 Niemann-Pick disease, type C2
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PEX11A peroxisomal biogenesis factor 11 alpha
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PPAP2A phosphatidic acid phosphatase type 2A
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RHOC ras homolog family member C
SCAND1 SCAN domain containing 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIK1 salt-inducible kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC44A4 solute carrier family 44, member 4
SPDEF SAM pointed domain containing ETS transcription factor
SQSTM1 sequestosome 1
SYNM synemin, intermediate filament protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMCO1 transmembrane and coiled-coil domains 1
TPM1 tropomyosin 1 (alpha)
TRAPPC3 trafficking protein particle complex 3
TRPM4 transient receptor potential cation channel, subfamily M, member 4
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
C20ORF27 chromosome 20 open reading frame 27
CCNB2 cyclin B2
CCND2 cyclin D2
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CHGB chromogranin B
CLU clusterin
COL1A2 collagen, type I, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
DHFR dihydrofolate reductase
DPYD dihydropyrimidine dehydrogenase
DTX4 deltex 4, E3 ubiquitin ligase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8 epidermal growth factor receptor pathway substrate 8
FAM129A family with sequence similarity 129, member A
FILIP1L filamin A interacting protein 1-like
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRB7 growth factor receptor-bound protein 7
GUSBP11 glucuronidase, beta pseudogene 11
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGB2 high mobility group box 2
HOPX HOP homeobox
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
L1CAM L1 cell adhesion molecule
LMNB1 lamin B1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPH non-SMC condensin I complex, subunit H
NMU neuromedin U
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NREP neuronal regeneration related protein
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLK2 polo-like kinase 2
PRR7 proline rich 7 (synaptic)
PRSS21 protease, serine, 21 (testisin)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN2 regulator of calcineurin 2
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SMC1A structural maintenance of chromosomes 1A
ST7 suppression of tumorigenicity 7
STAR steroidogenic acute regulatory protein
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
TKT transketolase
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN12 tetraspanin 12
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
WFDC1 WAP four-disulfide core domain 1