BRD-K16533489_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

228 genes differentially expressed following the BRD-K16533489_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARC activity-regulated cytoskeleton-associated protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN3 claudin 3
CLDN4 claudin 4
CPE carboxypeptidase E
CRY1 cryptochrome circadian clock 1
CSTA cystatin A (stefin A)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF4A1 eukaryotic translation initiation factor 4A1
ELF5 E74-like factor 5 (ets domain transcription factor)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTF2B general transcription factor IIB
GUSBP11 glucuronidase, beta pseudogene 11
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGLV2-23 immunoglobulin lambda variable 2-23
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF8 interferon regulatory factor 8
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCL1 myeloid cell leukemia 1
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF165 zinc finger protein 165
ZNF195 zinc finger protein 195
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACP6 acid phosphatase 6, lysophosphatidic
AK4 adenylate kinase 4
ANXA6 annexin A6
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
B3GNT1
BST2 bone marrow stromal cell antigen 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CBR3 carbonyl reductase 3
CCNF cyclin F
CD99 CD99 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COASY CoA synthase
COG2 component of oligomeric golgi complex 2
COL5A1 collagen, type V, alpha 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK1 death-associated protein kinase 1
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECI2 enoyl-CoA delta isomerase 2
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERLIN2 ER lipid raft associated 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM134C family with sequence similarity 134, member C
FAM162A family with sequence similarity 162, member A
GAS2L1 growth arrest-specific 2 like 1
GLUL glutamate-ammonia ligase
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IQGAP2 IQ motif containing GTPase activating protein 2
KANK2 KN motif and ankyrin repeat domains 2
KDM3A lysine (K)-specific demethylase 3A
KIAA0100 KIAA0100
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGED1 melanoma antigen family D1
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NUDCD3 NudC domain containing 3
PCGF2 polycomb group ring finger 2
PCYOX1L prenylcysteine oxidase 1 like
PEBP1 phosphatidylethanolamine binding protein 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPIC peptidylprolyl isomerase C (cyclophilin C)
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
TBC1D16 TBC1 domain family, member 16
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNS3 tensin 3
TRAK2 trafficking protein, kinesin binding 2
TSPAN3 tetraspanin 3
TUBB6 tubulin, beta 6 class V
TXNIP thioredoxin interacting protein
ZBTB18 zinc finger and BTB domain containing 18