BRD-K16485616_mocetinostat_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K16485616_mocetinostat_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ANXA5 annexin A5
AREG amphiregulin
ARF3 ADP-ribosylation factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
CALD1 caldesmon 1
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CNTNAP2 contactin associated protein-like 2
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL5 ELOVL fatty acid elongase 5
EPHB2 EPH receptor B2
ETNK1 ethanolamine kinase 1
FABP1 fatty acid binding protein 1, liver
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLIPR1 GLI pathogenesis-related 1
GSTM3 glutathione S-transferase mu 3 (brain)
HEBP1 heme binding protein 1
HLTF helicase-like transcription factor
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
INHBA inhibin, beta A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0040 KIAA0040
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LYN LYN proto-oncogene, Src family tyrosine kinase
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MIR22HG MIR22 host gene
MMD monocyte to macrophage differentiation-associated
MMP3 matrix metallopeptidase 3
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1B myosin IB
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PELI2 pellino E3 ubiquitin protein ligase family member 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PKP2 plakophilin 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB31 RAB31, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RFK riboflavin kinase
RHOBTB3 Rho-related BTB domain containing 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAD Ras-related associated with diabetes
SDC2 syndecan 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPEN spen family transcriptional repressor
STMN2 stathmin 2
STOM stomatin
SYT1 synaptotagmin I
TAGLN transgelin
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TKT transketolase
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VNN1 vanin 1
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
CBR3 carbonyl reductase 3
CCNB2 cyclin B2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COPS7A COP9 signalosome subunit 7A
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DST dystonin
ELF5 E74-like factor 5 (ets domain transcription factor)
EPHA3 EPH receptor A3
EPN2 epsin 2
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FOXG1 forkhead box G1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HEATR1 HEAT repeat containing 1
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KAT6B K(lysine) acetyltransferase 6B
KIAA0101 KIAA0101
LTF lactotransferrin
LYZ lysozyme
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MOXD1 monooxygenase, DBH-like 1
MYCBP MYC binding protein
NMI N-myc (and STAT) interactor
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PMM2 phosphomannomutase 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRTN3 proteinase 3
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCRG1 stimulator of chondrogenesis 1
SHCBP1 SHC SH2-domain binding protein 1
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP6 thyroid hormone receptor interactor 6
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1