BRD-K16485616_mocetinostat_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

205 genes differentially expressed following the BRD-K16485616_mocetinostat_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRE2 adhesion G protein-coupled receptor E2
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL2A1 BCL2-related protein A1
BHLHE41 basic helix-loop-helix family, member e41
CD52 CD52 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COTL1 coactosin-like F-actin binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CREM cAMP responsive element modulator
CTSB cathepsin B
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FBN2 fibrillin 2
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXO4 forkhead box O4
GALC galactosylceramidase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GOLM1 golgi membrane protein 1
GPR137B G protein-coupled receptor 137B
HIST1H2AC histone cluster 1, H2ac
HMG20B high mobility group 20B
HOXA10 homeobox A10
HPCAL1 hippocalcin-like 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD2 interferon-related developmental regulator 2
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IQGAP1 IQ motif containing GTPase activating protein 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT17 keratin 17, type I
LGMN legumain
LRP10 low density lipoprotein receptor-related protein 10
MAN1C1 mannosidase, alpha, class 1C, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NLRP2 NLR family, pyrin domain containing 2
NPTX2 neuronal pentraxin II
OPTN optineurin
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG3 paternally expressed 3
PFKM phosphofructokinase, muscle
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2A phosphatidic acid phosphatase type 2A
PRRC2C proline-rich coiled-coil 2C
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOQ ras homolog family member Q
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RUNX3 runt-related transcription factor 3
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SFRP4 secreted frizzled-related protein 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNX11 sorting nexin 11
SOX9 SRY (sex determining region Y)-box 9
SPON1 spondin 1, extracellular matrix protein
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STOM stomatin
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TMPRSS3 transmembrane protease, serine 3
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VWA5A von Willebrand factor A domain containing 5A
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACAT1 acetyl-CoA acetyltransferase 1
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
AQP3 aquaporin 3 (Gill blood group)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATMIN ATM interactor
BIRC5 baculoviral IAP repeat containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CENPB centromere protein B, 80kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSNK1A1 casein kinase 1, alpha 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
ELOVL2 ELOVL fatty acid elongase 2
ELP5 elongator acetyltransferase complex subunit 5
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FLG filaggrin
GLOD4 glyoxalase domain containing 4
GPSM2 G-protein signaling modulator 2
GRWD1 glutamate-rich WD repeat containing 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HN1L hematological and neurological expressed 1-like
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
IGHD immunoglobulin heavy constant delta
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LY6D lymphocyte antigen 6 complex, locus D
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOA monoamine oxidase A
MAPK13 mitogen-activated protein kinase 13
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PKP1 plakophilin 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRELP proline/arginine-rich end leucine-rich repeat protein
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PXMP2 peroxisomal membrane protein 2, 22kDa
RANBP1 RAN binding protein 1
RELN reelin
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A12 S100 calcium binding protein A12
SELENBP1 selenium binding protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SPRR1A small proline-rich protein 1A
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TP53 tumor protein p53
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
U2SURP U2 snRNP-associated SURP domain containing
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WHSC1 Wolf-Hirschhorn syndrome candidate 1