BRD-K16485616_mocetinostat_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K16485616_mocetinostat_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ADAM9 ADAM metallopeptidase domain 9
ADIPOQ adiponectin, C1Q and collagen domain containing
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOD apolipoprotein D
AREG amphiregulin
AXL AXL receptor tyrosine kinase
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42 cell division cycle 42
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL1A1 collagen, type I, alpha 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTBP2 C-terminal binding protein 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP1 dual specificity phosphatase 1
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FZD6 frizzled class receptor 6
GLS glutaminase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLM1 golgi membrane protein 1
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL7R interleukin 7 receptor
ISOC1 isochorismatase domain containing 1
JAG1 jagged 1
KRT6B keratin 6B, type II
MAPT microtubule-associated protein tau
MSMO1 methylsterol monooxygenase 1
MYOF myoferlin
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE4 ribonuclease, RNase A family, 4
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM9SF3 transmembrane 9 superfamily member 3
TRPS1 trichorhinophalangeal syndrome I
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VTCN1 V-set domain containing T cell activation inhibitor 1
WSB1 WD repeat and SOCS box containing 1
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ADCY9 adenylate cyclase 9
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIM2 absent in melanoma 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BCL2A1 BCL2-related protein A1
C2CD5 C2 calcium-dependent domain containing 5
CD79A CD79a molecule, immunoglobulin-associated alpha
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CTSH cathepsin H
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
FGFR3 fibroblast growth factor receptor 3
HCAR3 hydroxycarboxylic acid receptor 3
IGHD immunoglobulin heavy constant delta
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MPC2 mitochondrial pyruvate carrier 2
MSMB microseminoprotein, beta-
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEB nebulin
NREP neuronal regeneration related protein
OBSL1 obscurin-like 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PNMA2 paraneoplastic Ma antigen 2
POU2AF1 POU class 2 associating factor 1
PXMP2 peroxisomal membrane protein 2, 22kDa
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCAND1 SCAN domain containing 1
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLPI secretory leukocyte peptidase inhibitor
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNNC1 troponin C type 1 (slow)
ZIC1 Zic family member 1
ZNF512B zinc finger protein 512B