BRD-K16485616_mocetinostat_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K16485616_mocetinostat_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACOT7 acyl-CoA thioesterase 7
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BLNK B-cell linker
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
EDNRB endothelin receptor type B
EMX2 empty spiracles homeobox 2
FABP1 fatty acid binding protein 1, liver
FAM63A family with sequence similarity 63, member A
FBXO2 F-box protein 2
FN1 fibronectin 1
FOXJ3 forkhead box J3
FTH1 ferritin, heavy polypeptide 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
HEBP1 heme binding protein 1
HOOK2 hook microtubule-tethering protein 2
HOXA5 homeobox A5
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INPP5F inositol polyphosphate-5-phosphatase F
IQGAP1 IQ motif containing GTPase activating protein 1
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LIPA lipase A, lysosomal acid, cholesterol esterase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MNAT1 MNAT CDK-activating kinase assembly factor 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
OPN3 opsin 3
PHGDH phosphoglycerate dehydrogenase
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKCH protein kinase C, eta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS2 regulator of G-protein signaling 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN2 reticulon 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SKAP2 src kinase associated phosphoprotein 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A1 solute carrier family 38, member 1
STOM stomatin
TGFA transforming growth factor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM30B transmembrane protein 30B
TNIK TRAF2 and NCK interacting kinase
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
VNN1 vanin 1
WFS1 Wolfram syndrome 1 (wolframin)

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALCAM activated leukocyte cell adhesion molecule
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CBR3 carbonyl reductase 3
CCDC92 coiled-coil domain containing 92
CCL2 chemokine (C-C motif) ligand 2
CD59 CD59 molecule, complement regulatory protein
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CKAP4 cytoskeleton-associated protein 4
CXCL10 chemokine (C-X-C motif) ligand 10
DCN decorin
ECT2 epithelial cell transforming 2
EGF epidermal growth factor
EHF ets homologous factor
EYA2 EYA transcriptional coactivator and phosphatase 2
FASTKD5 FAST kinase domains 5
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GPX1 glutathione peroxidase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
IRAK1 interleukin-1 receptor-associated kinase 1
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LCN2 lipocalin 2
LMNB1 lamin B1
LTF lactotransferrin
LUM lumican
LY6D lymphocyte antigen 6 complex, locus D
MARCKS myristoylated alanine-rich protein kinase C substrate
NUP88 nucleoporin 88kDa
PBK PDZ binding kinase
PDLIM1 PDZ and LIM domain 1
PDZK1IP1 PDZK1 interacting protein 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK1 polo-like kinase 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RBM3 RNA binding motif (RNP1, RRM) protein 3
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SHCBP1 SHC SH2-domain binding protein 1
SPAG7 sperm associated antigen 7
TCEAL4 transcription elongation factor A (SII)-like 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSPYL5 TSPY-like 5
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
VCAN versican
WBP5 WW domain binding protein 5
WSB2 WD repeat and SOCS box containing 2
ZIC1 Zic family member 1