BRD-K16485616_S1122_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K16485616_S1122_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ANXA1 annexin A1
AOX1 aldehyde oxidase 1
BCL6 B-cell CLL/lymphoma 6
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3AR1 complement component 3a receptor 1
C7 complement component 7
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD24 CD24 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CHGB chromogranin B
CLEC7A C-type lectin domain family 7, member A
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
CPM carboxypeptidase M
CPVL carboxypeptidase, vitellogenic-like
CRP C-reactive protein, pentraxin-related
CSTA cystatin A (stefin A)
DEFB1 defensin, beta 1
DUSP1 dual specificity phosphatase 1
E2F2 E2F transcription factor 2
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FMO3 flavin containing monooxygenase 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GC group-specific component (vitamin D binding protein)
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HRASLS HRAS-like suppressor
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
INPP1 inositol polyphosphate-1-phosphatase
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LST1 leukocyte specific transcript 1
NGRN neugrin, neurite outgrowth associated
NMU neuromedin U
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PID1 phosphotyrosine interaction domain containing 1
PLAT plasminogen activator, tissue
PTN pleiotrophin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
STC1 stanniocalcin 1
STMN2 stathmin 2
SUSD4 sushi domain containing 4
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TRHDE thyrotropin-releasing hormone degrading enzyme

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AK4 adenylate kinase 4
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATF5 activating transcription factor 5
ATMIN ATM interactor
AUTS2 autism susceptibility candidate 2
BMI1 BMI1 proto-oncogene, polycomb ring finger
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD69 CD69 molecule
CDC25A cell division cycle 25A
CHL1 cell adhesion molecule L1-like
CHPT1 choline phosphotransferase 1
CLIC4 chloride intracellular channel 4
CNOT7 CCR4-NOT transcription complex, subunit 7
DLC1 DLC1 Rho GTPase activating protein
ECI2 enoyl-CoA delta isomerase 2
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
JMJD6 jumonji domain containing 6
LAMC1 laminin, gamma 1 (formerly LAMB2)
LYPLA1 lysophospholipase I
MALT1 MALT1 paracaspase
MARCKSL1 MARCKS-like 1
MTUS1 microtubule associated tumor suppressor 1
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PALB2 partner and localizer of BRCA2
PCM1 pericentriolar material 1
PLK1 polo-like kinase 1
RNMT RNA (guanine-7-) methyltransferase
RSAD1 radical S-adenosyl methionine domain containing 1
SMAD1 SMAD family member 1
SRP72 signal recognition particle 72kDa
TMEM97 transmembrane protein 97