BRD-K16478699_PLX-4720_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K16478699_PLX-4720_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
CAPN2 calpain 2, (m/II) large subunit
CD9 CD9 molecule
CDA cytidine deaminase
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFLAR CASP8 and FADD-like apoptosis regulator
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB5 integrin, beta 5
JAG1 jagged 1
JMJD6 jumonji domain containing 6
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LGALS8 lectin, galactoside-binding, soluble, 8
LPXN leupaxin
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL1 muscleblind-like splicing regulator 1
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL3 oxysterol binding protein-like 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RGCC regulator of cell cycle
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC35F2 solute carrier family 35, member F2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
STK17B serine/threonine kinase 17b
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TOMM34 translocase of outer mitochondrial membrane 34
TPM4 tropomyosin 4
TRIB1 tribbles pseudokinase 1
WWTR1 WW domain containing transcription regulator 1
ZYX zyxin

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AQP4 aquaporin 4
ASS1 argininosuccinate synthase 1
C1S complement component 1, s subcomponent
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCNB2 cyclin B2
CD40 CD40 molecule, TNF receptor superfamily member 5
CD99 CD99 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DMD dystrophin
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GOLGA8H golgin A8 family, member H
GPM6B glycoprotein M6B
GREB1 growth regulation by estrogen in breast cancer 1
GSTA4 glutathione S-transferase alpha 4
GYG2 glycogenin 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHM immunoglobulin heavy constant mu
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
P3H2 prolyl 3-hydroxylase 2
PDLIM1 PDZ and LIM domain 1
PI3 peptidase inhibitor 3, skin-derived
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PTN pleiotrophin
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPARCL1 SPARC-like 1 (hevin)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a